130532-92-2

Basic information

• Product Name: 5-chloro-3-phenyl-pyridin-2-ylamine
• Synonyms: 5-chloro-3-phenyl-pyridin-2-ylamine
• CAS NO: 130532-92-2
• Molecular Weight: 204.659
• Mol File: 130532-92-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-chloro-3-phenyl-pyridin-2-ylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-3-phenyl-pyridin-2-ylamine(130532-92-2)
• EPA Substance Registry System: 5-chloro-3-phenyl-pyridin-2-ylamine(130532-92-2)

Safety Data

• Hazardous Substances Data: 130532-92-2(Hazardous Substances Data)

Upstream product

• 171774-38-2 N-(3-bromo-5-chloropyridin-2-yl)pyridin-1-ium-1-aminide 
• 100-39-0 benzyl bromide 
• 26163-03-1 2-amino-3-bromo-5-chloropyridine 
• 98-80-6 phenylboronic acid 
• 17180-94-8 5-chloropyrimidine 
• 140-29-4 phenylacetonitrile 

Relevant articles and documents

Pyridinium N-2′-pyridylaminide: radical cyclization for the synthesis of benzonaphthyridine derivatives

The synthesis of benzonaphthyridine derivatives that incorporate a 2-aminopyridine moiety can be performed by intramolecular radical pyridylation of the appropriate substrates, obtained from pyridinium N-2′-pyridylaminide, using TTMSS and AIBN.

REACTIONS OF β-BROMO-N-HETEROAROMATICS WITH PHENYLACETONITRILE

The reaction of 3-bromopyridine with phenylacetonitrile in the presence of NaH in THF gave a simple substitution product, α-phenyl-3-pyridineacetonitrile, whereas the reaction of 5-bromopyrimidine with phenylacetonitrile under similar conditions gave a ring-transformation product, 2-amino-5-bromo-3-phenylpyridine. 3-Bromoquinoline and 4-bromoisoquinoline underwent the former type reaction, while 3-bromo- and 3-chloroisoquinolines were converted into 2-amino-3-phenyl-1-naphthalenecarbonitrile according to the latter type reaction.