130606-00-7

Basic information

• Product Name: 2-Piperidinecarbonyl chloride (9CI)
• Synonyms: 2-Piperidinecarbonyl chloride (9CI)
• CAS NO: 130606-00-7
• Molecular Formula: C₆H₁₀ClNO
• Molecular Weight: 147.6027
• Product Categories: ACIDHALIDE
• Mol File: 130606-00-7.mol
• Article Data: 3

Chemical Properties

• Melting Point: 265-266 °C
• Boiling Point: 199.8±33.0 °C(Predicted)
• Appearance: /
• Density: 1.147±0.06 g/cm3(Predicted)
• PKA: 7.83±0.10(Predicted)
• CAS DataBase Reference: 2-Piperidinecarbonyl chloride (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Piperidinecarbonyl chloride (9CI)(130606-00-7)
• EPA Substance Registry System: 2-Piperidinecarbonyl chloride (9CI)(130606-00-7)

Safety Data

• Hazardous Substances Data: 130606-00-7(Hazardous Substances Data)

Upstream product

• 130497-14-2 (+/-)-[(N-ethoxycarbonyl)piperidine]-2-carboxylic acid 
• 15862-86-9 piperidine-2-carboxylic acid hydrochloride 
• 4043-87-2 pipecolic Acid 

Downstream Products

• 130605-98-0 1-(2-piperidinylcarbonyl)pyrrolidine 
• 130497-29-9 Piperidine-2-carboxylic acid dimethylamide 
• 99552-32-6 pipecolic acid-2,4-xylidide 
• 60717-51-3 (2R,S)-2-dimethylaminomethyl piperidine 
• 100158-63-2 2-[(1-Pyrrolidinyl)methyl]piperidine 
• 128103-41-3 [3H]-BRL 52537 
• 130497-48-2 2-(4-Cyclohexyl-phenyl)-1-(2-pyrrolidin-1-ylmethyl-piperidin-1-yl)-ethanone 
• 115642-89-2 2-(3-Nitro-phenyl)-1-(2-pyrrolidin-1-ylmethyl-piperidin-1-yl)-ethanone 
• 130497-43-7 2-(4-Nitro-phenyl)-1-(2-pyrrolidin-1-ylmethyl-piperidin-1-yl)-ethanone 
• 115642-90-5 1-(2-Pyrrolidin-1-ylmethyl-piperidin-1-yl)-2-(3-trifluoromethyl-phenyl)-ethanone 

Relevant articles and documents

Optical Control of a Delayed Rectifier and a Two-Pore Potassium Channel with a Photoswitchable Bupivacaine

Photoswitchable blockers of potassium channels can be used to optically control neuronal excitability and hold great promise for vision restoration. Here, we report a series of improved photoswitchable blockers that feature a new pharmacophore based on the local anesthetic bupivacaine. These azobupivacaines (ABs) enable optical control over the delayed rectifier channel Kv2.1. and target the two-pore domain potassium channel TREK-1. For the first time, we have identified a compound that blocks conductance in the dark and potentiates it upon illumination. Using light as a trigger, ABs efficiently and reversibly silence action potential firing of hippocampal neurons in acute mouse brain slices.

(2S)-1-(arylacetyl)-2-(aminomethyl)piperidine derivatives: Novel, highly selective κ opioid analgesics

This paper describes the synthesis and structure-activity relationships as κ opioid analgesics of a novel class of 1-(arylacetyl)-2-(aminomethyl)piperidine derivatives (8). The active conformation of the pharmacophore, with a torsional angle (N1C2C7N8) of 60°, was defined with computational studies and 1H NMR. A quantitative structure-activity relationship study of the arylacetic moiety substitution indicated that the presence of an electron-withdrawing and lipophilic substituent in para and/or meta positions is required for good analgesic activity and κ affinity. The lead compounds (2S)-1-[(3,4-dichlorophenyl)acetyl]-2-(pyrrolidin-1-ylmethyl) piperidine hydrochloride (14) and (2S)-1-[[4-(trifluoromethyl)phenyl]acetyl]-2-(pyrrolidin-1- ylmethyl)piperidine hydrochloride (21) are the most κ/μ selective (respectively 6500:1 and 4100:1) and among the most potent (K(i) κ 0.24 and 0.57 nM, respectively) κ ligands identified so far. In the mouse tail flick model of antinociception, compound 14 (ED50 = 0.05 mg/kg sc) was 25 times more potent than morphine and 16 times more potent than the standard κ ligand U-50488.