130676-57-2 Usage
Description
2',3'-Didehydro-2',3'-dideoxy-5'-acetate inosine is a chemical compound derived from inosine, a nucleoside found in the body. It is characterized by the absence of two hydroxyl groups at the 2' and 3' positions and the presence of a double bond at the same positions. Additionally, it has an acetate group attached to the 5' position. This modification of the inosine molecule may alter its properties and potential applications.
Uses
Used in Pharmaceutical Industry:
2',3'-Didehydro-2',3'-dideoxy-5'-acetate inosine is used as an impurity in Inosine Pranobex, a formulation that is known to positively impact a host's immune system. Inosine Pranobex has been studied for its potential benefits in various conditions, including chronic fatigue syndrome and certain types of cancer, by modulating the immune response.
Used in Research and Development:
As a derivative of inosine, 2',3'-Didehydro-2',3'-dideoxy-5'-acetate inosine may be utilized in research and development for understanding the structure-activity relationships of nucleoside analogs. This could lead to the discovery of new therapeutic agents with improved pharmacological properties or novel applications in the treatment of various diseases.
Used in Quality Control and Analysis:
The presence of 2',3'-Didehydro-2',3'-dideoxy-5'-acetate inosine as an impurity in Inosine Pranobex necessitates its analysis and quantification in the quality control process. This ensures the safety, efficacy, and consistency of the pharmaceutical product, which is crucial for patient well-being and compliance with regulatory standards.
Check Digit Verification of cas no
The CAS Registry Mumber 130676-57-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,0,6,7 and 6 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 130676-57:
(8*1)+(7*3)+(6*0)+(5*6)+(4*7)+(3*6)+(2*5)+(1*7)=122
122 % 10 = 2
So 130676-57-2 is a valid CAS Registry Number.
130676-57-2Relevant articles and documents
Synthesis of 2',3'-dideoxy-2',3'-didehydro nucleosides via a serendipitous route.
Guo,Sanghvi,Brammer Jr.,Hudlicky
, p. 1263 - 1266 (2001)
This paper describes a "green" synthesis of 2',3'-unsaturated 2',3'-dideoxynucleosides via an electrochemical reaction. Using this approach d4T, d4U, ddA and ddI can be synthesized in high yields.
Synthesis of haptens for the development of immunoassays for the monitoring of intracellular anti-HIV nucleosides and nucleotides
Brossette, Thierry,Klein, Emmanuel,Créminon, Christophe,Grassi, Jacques,Mioskowski, Charles,Lebeau, Luc
, p. 8129 - 8143 (2007/10/03)
A series of nine modified dideoxynucleosides and dideoxynucleotides has been synthesized for preparing antigenic conjugates with keyhole lympet haemocyanin in order to produce specific antibodies, and develop immunoassays. Derivatives of ddI, ddA, d4T, 3TC, and the corresponding 5′-O-monophosphates were designed incorporating an amino spacer at the base for conjugation with the proteinic antigenic carrier.
An efficient and general synthesis of 5'-esters of 2',3'-didehydro-2',3'-dideoxynucleosides: A facile opening of 2',3'-orthoacetates of ribonucleosides followed by reductive elimination of the halogenoacetates
Talekar,Coe,Walker
, p. 303 - 306 (2007/10/02)
A three-step reaction sequence from a ribonucleoside to give the corresponding 5'-O-acyl-2',3'-didehydro-2',3'-dideoxynucleoside is described. The key intermediate is the bromoacetate, made by reaction of the 2',3'-methoxyethylidine nucleoside with acetyl bromide. Reductive elimination of the bromoacetate using a zinc-copper couple furnishes the desired compounds in good overall yield.
