130800-76-9 Usage
Description
Isoxazole, 5-(3-chloropropyl)-3-methyl(9CI) is an organic compound characterized by its isoxazole ring structure with a 3-chloropropyl group at the 5-position and a methyl group at the 3-position. It is a colorless oil, indicating its liquid state at room temperature and its lack of color.
Uses
Used in Pharmaceutical Industry:
Isoxazole, 5-(3-chloropropyl)-3-methyl(9CI) is used as an intermediate in the preparation of Picornavirus replication inhibitors. These inhibitors are essential in the development of antiviral drugs targeting Picornaviruses, a family of RNA viruses that cause various illnesses, including the common cold, polio, and hepatitis A.
As an intermediate, Isoxazole, 5-(3-chloropropyl)-3-methyl(9CI) plays a crucial role in the synthesis of the final antiviral compounds. Its unique chemical structure allows for further functionalization and modification to enhance the potency and selectivity of the resulting Picornavirus replication inhibitors. This application is significant in the ongoing efforts to combat viral infections and develop new therapeutic strategies against emerging and existing viral diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 130800-76-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,0,8,0 and 0 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 130800-76:
(8*1)+(7*3)+(6*0)+(5*8)+(4*0)+(3*0)+(2*7)+(1*6)=89
89 % 10 = 9
So 130800-76-9 is a valid CAS Registry Number.
InChI:InChI=1/C7H10ClNO/c1-6-5-7(10-9-6)3-2-4-8/h5H,2-4H2,1H3
130800-76-9Relevant articles and documents
1,2,4-OXADIAZOLYL-PHENOXYALKYLISOXAZOLES AND THEIR USE AS ANTIVIRAL AGENTS
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, (2008/06/13)
Compounds of the formula wherein: R1 is alkyl, alkoxy, hydroxy, cycloalkyl, hydroxyalkyl, alkoxyalkyl, hydroxyalkoxy, alkylthioalkyl, alkylsulfinylalkyl, alkylsulfonylalkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, alkoxycarbonyl, carboxy, or cyanomethyl; Y is alkylene of 3 to 9 carbon atoms, R2 and R3 independently are hydrogen, alkyl, alkoxy, halo, cyano, trifluoromethyl and nitro; R4 is alkoxy, hydroxy, halomethyl, dihalomethyl, trihalomethyl, dihaloethyl, cycloalkyl, heterocyclyl, alkoxycarbonyl, hydroxyalkyl, alkoxyalkyl, alkanecarbonyloxyalkyl, cyano, halo, thioalkyl, alkylthioalkyl, alkylthio, thio, 2,2,2-trifluoro-ethyl, (4-methylphenyl)sulfonyloxymethyl, N=Q or CON=Q, where N=Q is amino, alkylamino or dialkylamino; R5 is hydrogen or halo or alkyl
Conformationally restricted analogues of disoxaril: A comparison of the activity against human rhinovirus types 14 and 1A
Mallamo,Diana,Pevear,Dutko,Chapman,Kim,Minor,Oliveira,Rossmann
, p. 4690 - 4695 (2007/10/02)
A series of conformationally restricted analogs of disoxaril has been synthesized and evaluated against human rhinovirus types (HRV) 14 and 1A. The sensitivity of these serotypes to this series varied and was dependent upon the length of the molecule as w
