1309457-35-9

Basic information

• Product Name: 5-(2,4-Difluorophenyl)-3H-1,2,4-dithiazol-3-thione
• CAS NO: 1309457-35-9
• Molecular Weight: 247.313
• Mol File: 1309457-35-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-(2,4-Difluorophenyl)-3H-1,2,4-dithiazol-3-thione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2,4-Difluorophenyl)-3H-1,2,4-dithiazol-3-thione(1309457-35-9)
• EPA Substance Registry System: 5-(2,4-Difluorophenyl)-3H-1,2,4-dithiazol-3-thione(1309457-35-9)

Safety Data

• Hazardous Substances Data: 1309457-35-9(Hazardous Substances Data)

Upstream product

• 175276-92-3 2,4-difluorobenzene-1-carbothioamide 

Relevant articles and documents

SULFUR TRANSFER REAGENTS FOR OLIGONUCLEOTIDE SYNTHESIS

The use of N-formamidino-5-amino-3H-1,2,4-dithiazole-3-thiones, 5-phenyl-3H-1,2,4-dithiazole-3-thiones, and derivatives thereof as novel, efficient sulfur-transfer reagents is disclosed. Sulfur transfer from these reagents to compounds containing a P(III) atom (e.g., triphenylphosphine, 5′-O-DMT-thymidine 2-cyanoethyl-(N,N-diisopropyl)phosphoramidite, and 5′-O-DMT-3′-O-levulinyl dithymidilyl 2-cyanoethyl phosphite), was studied in solution by 31P NMR and HPLC. The sulfur transfer from title compounds was also studied in the solid-phase synthesis of oligonucleotide phosphorothioates by phosphoramidite methods. In this application, the efficiency of the sulfur transfer reaction for 2′-deoxyoligonucleotides was better than 99.5%. The novel sulfurizing agents are synthesized, at low cost, using simple chemical methods. As opposed to many sulfur transfer reagents known in the prior art such as 1,2-benzodithiol-3-one-1,1-dioxide (Beaucage reagent) and 5-ethoxy-3H-1,2,4-dithiazole-2-one (EDIT), the sulfurizing agents disclosed herein are highly stable in solution, which increases their practical and commercial value.