130973-54-5

Basic information

• Product Name: Benzenesulfinic acid, 2-[1-[(2,2-dimethyl-1-oxopropyl)amino]ethyl]-, (R)-
• CAS NO: 130973-54-5
• Molecular Formula: C13H19NO3S
• Molecular Weight: 269.365
• Mol File: 130973-54-5.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Benzenesulfinic acid, 2-[1-[(2,2-dimethyl-1-oxopropyl)amino]ethyl]-, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfinic acid, 2-[1-[(2,2-dimethyl-1-oxopropyl)amino]ethyl]-, (R)-(130973-54-5)
• EPA Substance Registry System: Benzenesulfinic acid, 2-[1-[(2,2-dimethyl-1-oxopropyl)amino]ethyl]-, (R)-(130973-54-5)

Safety Data

• Hazardous Substances Data: 130973-54-5(Hazardous Substances Data)

Upstream product

• 3282-30-2 pivaloyl chloride 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 144434-12-8 (R)-(+)-o-(1-pivaloylaminoethyl)thiophenol 
• 91797-84-1 (R)-(+)-N-(1-phenylethyl)-2,2-dimethylpropanamide 
• 139343-81-0 (S_(S)R)-(+)-3-methyl-2-pivaloyl-2,3-dihydroisothiazole 1-oxide 
• 139223-55-5 (2S,3S)-2-{(S)-2-[(R)-1-(2,2-Dimethyl-propionylamino)-ethyl]-benzenesulfinyl}-3-hydroxy-3-phenyl-propionic acid tert-butyl ester 
• 139223-54-4 (S_(S)R)-tert-butyl o-<1-(tert-butylcarbonylamino)ethyl>phenylsulfinylacetate 

Downstream Products

• 139223-51-1 N-{(R)-1-[2-((S)-Methanesulfinyl)-phenyl]-ethyl}-2,2-dimethyl-propionamide 
• 139223-54-4 (S_(S)R)-tert-butyl o-<1-(tert-butylcarbonylamino)ethyl>phenylsulfinylacetate 
• 139223-55-5 (2S,3S)-2-{(S)-2-[(R)-1-(2,2-Dimethyl-propionylamino)-ethyl]-benzenesulfinyl}-3-hydroxy-3-phenyl-propionic acid tert-butyl ester 
• 144434-08-2 (2S,3S)-2-{(S)-2-[(R)-1-(2,2-Dimethyl-propionylamino)-ethyl]-benzenesulfinyl}-3-hydroxy-4,4-dimethyl-pentanoic acid tert-butyl ester 
• 144434-03-7 (2S,3S)-2-{(S)-2-[(R)-1-(2,2-Dimethyl-propionylamino)-ethyl]-benzenesulfinyl}-3-hydroxy-3-(4-methoxy-phenyl)-propionic acid tert-butyl ester 
• 144434-04-8 (2S,3S)-2-{(S)-2-[(R)-1-(2,2-Dimethyl-propionylamino)-ethyl]-benzenesulfinyl}-3-hydroxy-3-(3-methoxy-phenyl)-propionic acid tert-butyl ester 
• 144434-07-1 (2S,3S)-2-{(S)-2-[(R)-1-(2,2-Dimethyl-propionylamino)-ethyl]-benzenesulfinyl}-3-hydroxy-3-(2-nitro-phenyl)-propionic acid tert-butyl ester 
• 144434-06-0 (2S,3S)-2-{(S)-2-[(R)-1-(2,2-Dimethyl-propionylamino)-ethyl]-benzenesulfinyl}-3-hydroxy-3-(4-nitro-phenyl)-propionic acid tert-butyl ester 
• 139223-52-2 N-{(R)-1-[2-((S)-Butane-1-sulfinyl)-phenyl]-ethyl}-2,2-dimethyl-propionamide 
• 139223-53-3 2,2-Dimethyl-N-{(R)-1-[2-((S)-phenylmethanesulfinyl)-phenyl]-ethyl}-propionamide 
• 918811-02-6 sodium 2-((R)-1-pivalamidoethyl)benzenesulfinate 
• 144434-12-8 (R)-(+)-o-(1-pivaloylaminoethyl)thiophenol 

Relevant articles and documents

Chiral toluene-2,α-sultam auxiliaries: preparation and structure of enantiomerically pure (R)- and (S)-ethyl-2-1'-sultam

Crystalline sultams (R)-2 or (S)-2 were selectively prepared from prochiral saccharine (3) in two steps (53% overall yield) via Ru-(R)-BINAP- or Ru-(S)-BINAP catalyzed asymmetric hydrogenation of imine 4. Alternatively, pure (R)-2 was synthesized (37%) overall yield) from (R)-α-phenethylamine in 4-5 steps involving the ortho-sulfination 6→7 and the highly diastereoselective cyclization of sulfinic acid 7 to the sulfinamide 8. X-ray diffraction analyses of sulfinamide 8 and sultam (R)-2 are presented.

Phenylglycinamide and pyridylglycinamide derivatives useful as anticoagulants

The present invention provides novel phenylglycinamide derivatives of Formula (I) or (IV): or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate, or prodrug thereof, wherein the variables W, W1, Y, Z, R7, R8, R9, and R11 are as defined herein. These compounds are selective inhibitors of factor VIIa which can be used as medicaments.

Recoverable Chiral Sulfoxides for Asymmetric Synthesis: Preparation, Regeneration and Application to the Asymmetric Aldol Reaction

The synthesis of a novel source of chiral sulfoxide and its application to the control of asymmetric aldol reactions is described.The sulfoxide precursor S(S)R-(+)-cis-4 may be recycled and thus affords a considerable advantage over currently a