130973-78-3 Usage
Description
Azetidine-2-carboxamide is a chemical compound that plays a significant role in the development of pharmaceuticals, particularly as a key component in the discovery of NVP-BYL719 I. AZETIDINE-2-CARBOXAMIDE possesses unique structural and functional properties that make it a valuable asset in the field of medicinal chemistry.
Uses
Used in Pharmaceutical Industry:
Azetidine-2-carboxamide is used as a key component in the discovery of NVP-BYL719 I, a potent and selective phosphatidylinositol-3 kinase alpha inhibitor. This inhibitor is crucial in the development of targeted cancer therapies, as it helps to modulate the activity of the PI3K/AKT/mTOR pathway, which is often dysregulated in various types of cancer. By targeting this pathway, NVP-BYL719 I has the potential to offer a more effective and selective treatment option for cancer patients.
Furthermore, the use of azetidine-2-carboxamide in the development of NVP-BYL719 I highlights its potential as a building block for the synthesis of other pharmaceutical agents. Its unique properties and reactivity make it a valuable tool for medicinal chemists in the design and synthesis of novel therapeutic agents with improved efficacy and selectivity.
Check Digit Verification of cas no
The CAS Registry Mumber 130973-78-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,0,9,7 and 3 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 130973-78:
(8*1)+(7*3)+(6*0)+(5*9)+(4*7)+(3*3)+(2*7)+(1*8)=133
133 % 10 = 3
So 130973-78-3 is a valid CAS Registry Number.
InChI:InChI=1/C4H8N2O/c5-4(7)3-1-2-6-3/h3,6H,1-2H2,(H2,5,7)
130973-78-3Relevant articles and documents
COMPOUND INHIBITING DIPEPTIDYL PEPTIDASE IV
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Page/Page column 10, (2010/02/14)
The invention aims to provide a dipeptidyl peptidase IV inhibitor which is satisfactory in respect of activity, stability and safety and has an excellent action as a pharmaceutical agent. The invention is directed to a compound represented by the following general formula or a pharmaceutically acceptable salt thereof: wherein R1 and R2 each represents hydrogen, an optionally substituted C1-6 alkyl group, or -COOR5 whereupon R5 represents hydrogen or an optionally substituted C1-6 alkyl group, or R1 and R2, together with a carbon atom to which they are bound, represent a 3- to 6-membered cycloalkyl group, R3 represents hydrogen or an optionally substituted C6-10 aryl group, R4 represents a hydrogen or a cyano group, D represents -CONR6-, -CO- or -NR6CO-, R6 represents hydrogen or an optionally substituted C1-6 alkyl group, E represents -(CH2)m- whereupon m is an integer of 1 to 3, -CH2OCH2-, or -SCH2-, n is an integer of 0 to 3, and A represents an optionally substituted bicyclic heterocyclic group or bicyclic hydrocarbon group.