131002-02-3

Basic information

• Product Name: Benzamide, 2-bromo-5-chloro-
• CAS NO: 131002-02-3
• Molecular Formula: C7H5BrClNO
• Molecular Weight: 234.48
• Mol File: 131002-02-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzamide, 2-bromo-5-chloro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, 2-bromo-5-chloro-(131002-02-3)
• EPA Substance Registry System: Benzamide, 2-bromo-5-chloro-(131002-02-3)

Safety Data

• Hazardous Substances Data: 131002-02-3(Hazardous Substances Data)

Upstream product

• 618-48-4 3-chlorobenzamide 

Downstream Products

• 131002-05-6 5-chloro-2-ethenylbenzamide 
• 5202-85-7 2-Amino-5-chlorobenzamide 
• 4337-43-3 5-chloro-1,2-benzisothiazolin-3-one 
• 24188-74-7 7-chloroisoquinoline-1(2Η)-one 
• 64117-49-3 5-chloro-2-ethoxybenzamide 
• 82256-09-5 6-chloro-2-(4-methylphenyl)quinazolin-4(3H)-one 
• 1026-12-6 6-chloro-2-phenyl-3H-quinazolin-4-one 
• 19407-61-5 6-chloro-2-(4-methoxyphenyl)-4(3H)-quinazolinone 

Relevant articles and documents

Acid-promoted palladium(II)-catalyzed ortho-halogenation of primary benzamides: En route to halo-arenes

Br?nsted acid-promoted palladium(II)-catalyzed regioselective installation of halogens (Br, Cl, and I) to the aromatic ring of benzamide derivatives has been achieved using primary amides. A wide variety of benzamides were compatible under established conditions to afford the halogenated products without installing any external auxiliary. Mild reaction conditions, use of primary amide as a directing group, external additive-free conditions, and gram-scale reaction are some appealing features of this protocol. Detailed experimental results revealed that Br?nsted acid plays a critical role in this transformation.