13103-80-5 Usage
Description
3'-Hydroxypropiophenone is an organic compound that serves as an important intermediate in the synthesis of various pharmaceuticals and chemicals. It is characterized by its reactivity and functional groups, which allow for further chemical modifications and applications in different industries.
Uses
Used in Pharmaceutical Industry:
3'-Hydroxypropiophenone is used as a reactant for the synthesis of tricyclic fused pyridines, which are a family of alkaloids with significant antimalarial activity. This application is crucial in the development of new drugs to combat malaria, a disease that affects millions of people worldwide.
Used in Chemical Synthesis:
3'-Hydroxypropiophenone is also used as a building block in the synthesis of other complex organic molecules, making it a valuable compound in the chemical industry. Its versatility in reacting with various reagents allows for the creation of a wide range of products with diverse applications.
Preparation
Preparation by diazotization of m-aminopropiophenone, followed by decomposition of the diazonium salt obtained, (71%) Also obtained by saponification of 3-acetoxypropiophenone (b.p.2 127–128°) with refluxing 10% sodium hydroxide for 2–3 h (83%) Also obtained by reductive deamination of 2-amino-5-hydroxypropiophenone (diazotization, followed by decomposition of the diazonium salt formed with copper powder in ethanol) Also obtained by reaction of ethylmagnesium bromide with 3-hydroxy-N, N-diethylbenzamide in refluxing n-butyl ether for 4 h (75%) Also obtained by treatment of 3-methoxypropiophenone (b.p.0.05 70–76°) with pyridinium chloride at 210° for 30 min (85%) Also obtained by treatment of 1-hydroxy-1-(3-hydroxyphenyl)propane (m.p. 105–107°) with DDQ in dioxane for 72 h (97%).
Check Digit Verification of cas no
The CAS Registry Mumber 13103-80-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,1,0 and 3 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 13103-80:
(7*1)+(6*3)+(5*1)+(4*0)+(3*3)+(2*8)+(1*0)=55
55 % 10 = 5
So 13103-80-5 is a valid CAS Registry Number.
13103-80-5Relevant articles and documents
TETRAZOLINONE COMPOUND AND USE THEREOF
-
Paragraph 0487, (2016/09/12)
A tetrazolinone compound represented by formula (1): wherein R1 and R2 each represents a hydrogen atom, a halogen atom, or a C1-C3 alkyl group; R3 represents a C1-C3 alkyl group optionally having one or more halogen atoms; R4, R5, and R6 each represents a hydrogen atom or a halogen atom; R7 represents a C1-C3 alkyl group; Q represents a divalent group selected from Group P4; and A represents a C7-C18 aralkyloxy group optionally having one or more atoms or groups selected from Group P3, has excellent control activity against pests.
CHEMICAL COMPOUNDS
-
Page/Page column 30, (2008/06/13)
The present invention discloses to novel compounds with a variety of therapeutic uses. More particularly, the invention discloses novel symmetrical triphenyl compounds that are particularly useful for selective estrogen receptor modulation.
5-LIPOXYGENASE INHIBITORY THIAZOLES
-
, (2008/06/13)
The invention concerns a thiazole of the formula I, wherein Ar1 is optionally substituted aryl of up to 10 carbon atoms; A is a direct link to X, or is (1-6C)alkylene, (3-6C)alkenylene, (3-6C)alkynylene or cyclo(3-6C)alkylene; X is oxy, thio, sulphinyl, sulphonyl or imino; Ar2 is optionally substituted phenylene, or a 6-membered heterocyclene moiety containing up to three nitrogen atoms; R1 is hydrogen, (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl or substituted (1-4C)alkyl; R2 is hydrogen, (1-6C)alkyl, (3-6C)alkenyl, (3-6C)alkynyl, substituted (1-4C)alkyl or (2-6C)alkanoyl; Q is optionally substituted thiazolyl; or a pharmaceutically-acceptable salt thereof. The invention also concerns processes for the manufacture of a thiazole of the formula I, or a pharmaceutically-acceptable salt thereof, and pharmaceutical compositions containing said thiazole