1310416-76-2Relevant articles and documents
2-(2-Aminothiazol-4-yl)pyrrolidine-based tartrate diamides as potent, selective and orally bioavailable TACE inhibitors
Dai, Chaoyang,Li, Dansu,Popovici-Muller, Janeta,Zhao, Lianyun,Girijavallabhan, Vinay M.,Rosner, Kristin E.,Lavey, Brian J.,Rizvi, Razia,Shankar, Bandarpalle B.,Wong, Michael K.C.,Guo, Zhuyan,Orth, Peter,Strickland, Corey O.,Sun, Jing,Niu, Xiaoda,Chen, Shiying,Kozlowski, Joseph A.,Lundell, Daniel J.,Piwinski, John J.,Shih, Neng-Yang,Siddiqui, M. Arshad
, p. 3172 - 3176 (2011/06/24)
TNF-α converting enzyme (TACE) inhibitors are promising agents to treat inflammatory disorders and cancer. We have investigated novel tartrate diamide TACE inhibitors where the tartrate core binds to zinc in a unique tridentate fashion. Incorporating (R)-
