1310738-20-5Relevant articles and documents
The discovery of furo[2,3-c]pyridine-based indanone oximes as potent and selective B-Raf inhibitors
Buckmelter, Alex J.,Ren, Li,Laird, Ellen R.,Rast, Bryson,Miknis, Greg,Wenglowsky, Steve,Schlachter, Stephen,Welch, Mike,Tarlton, Eugene,Grina, Jonas,Lyssikatos, Joseph,Brandhuber, Barbara J.,Morales, Tony,Randolph, Nikole,Vigers, Guy,Martinson, Matthew,Callejo, Michele
, p. 1248 - 1252 (2011/04/16)
Virtual and high-throughput screening identified imidazo[1,2-a]pyrazines as inhibitors of B-Raf. We describe the rationale, SAR, and evolution of the initial hits to a series of furo[2,3-c]pyridine indanone oximes as highly potent and selective inhibitors
