1311401-88-3

Basic information

• Product Name: C₁₅H₂₀BrNO₄
• Synonyms: C₁₅H₂₀BrNO₄
• CAS NO: 1311401-88-3
• Molecular Weight: 358.232
• Mol File: 1311401-88-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₁₅H₂₀BrNO₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₅H₂₀BrNO₄(1311401-88-3)
• EPA Substance Registry System: C₁₅H₂₀BrNO₄(1311401-88-3)

Safety Data

• Hazardous Substances Data: 1311401-88-3(Hazardous Substances Data)

Upstream product

• 35458-39-0 4-bromo-2,5-dimethoxybenzoic acid 
• 31558-41-5 4-bromo-2,5-dimethoxybenzaldehyde 

Downstream Products

• 1311401-90-7 C₁₄H₁₆BrNO₃ 
• 1311401-92-9 C₁₆H₁₇NO₃ 

Relevant articles and documents

Synthesis and Biological Evaluation of Kibdelone C and Its Simplified Derivatives

Poylcyclic tetrahydroxanthones comprise a large class of cytototoxic natural products. No mechanism of action has been described for any member of the family. We report the synthesis of kibdelone C and several simplified analogs. Both enantiomers of kibdeleone C show low nanomolar cytotoxicity toward multiple human cancer cell lines. Moreover, several simplified derivatives with improved chemical stability display higher activity than the natural product itself. In vitro studies rule out interaction with DNA or inhibition of topoisomerase, both of which are common modes of action for polycyclic aromatic compounds. However, celluar studies reveal that kibdelone C and its simplified derivatives disrupt the actin cytoseketon without directly binding actin or affecting its polymerization in vitro.