1312996-84-1Relevant articles and documents
σ-Bond initiated generation of aryl radicals from aryl diazonium salts
Chan, Bun,McErlean, Christopher S. P.,Nashar, Philippe E.,Tatunashvili, Elene
supporting information, p. 1812 - 1819 (2020/03/17)
σ-Bond nucleophiles and molecular oxygen transform aryl diazonium salts into aryl radicals. Experimental and computational studies show that Hantzsch esters transfer hydride to aryl diazonium species, and that oxygen initiates radical fragmentation of the diazene intermediate to produce aryl radicals. The operational simplicity of this addition-fragmentation process for the generation of aryl radicals, by a polar-radical crossover mechanism, has been illustrated in a variety of bond-forming reactions.
Regioselective Suzuki coupling of dihaloheteroaromatic compounds as a rapid strategy to synthesize potent rigid combretastatin analogues
Theeramunkong, Sewan,Caldarelli, Antonio,Massarotti, Alberto,Aprile, Silvio,Caprioglio, Diego,Zaninetti, Roberta,Teruggi, Alessia,Pirali, Tracey,Grosa, Giorgio,Tron, Gian Cesare,Genazzani, Armando A.
supporting information; experimental part, p. 4977 - 4986 (2011/10/01)
Combretastatin A-4 (CA-4) is a potent tubulin depolymerizing agent able to inhibit tumor growth and with antivascular effects. Although it is in clinical trials, the search for novel analogues that may display better/different features is still ongoing. I
