1313613-18-1

Basic information

• Product Name: N-[4-(3-oxo-4-morpholinyl)phenyl]carbamic acid phenylmethyl ester
• CAS NO: 1313613-18-1
• Molecular Formula: C₁₈H₁₈N₂O₄
• Molecular Weight: 326.35192
• Mol File: 1313613-18-1.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: N-[4-(3-oxo-4-morpholinyl)phenyl]carbamic acid phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-[4-(3-oxo-4-morpholinyl)phenyl]carbamic acid phenylmethyl ester(1313613-18-1)
• EPA Substance Registry System: N-[4-(3-oxo-4-morpholinyl)phenyl]carbamic acid phenylmethyl ester(1313613-18-1)

Safety Data

• Hazardous Substances Data: 1313613-18-1(Hazardous Substances Data)

Usage

General Description

N-[4-(3-oxo-4-Morpholinyl)phenyl]carbaMic acid phenylMethyl ester is a chemical compound with the molecular formula C21H21NO5. It is a methyl ester derivative of carbaMic acid, with a nitrogen-containing morpholine ring and a phenyl group attached to the carboxyl group. N-[4-(3-oxo-4-Morpholinyl)phenyl]carbaMic acid phenylMethyl ester is often used as a reagent in organic synthesis and pharmaceutical research, particularly in the production of various pharmaceutical drugs. It has potential applications in the field of medicinal chemistry and drug development due to its structural features and reactivity. Its properties and potential uses make it an interesting and important chemical compound for further study and application in the pharmaceutical and chemical industries.

Upstream product

• 501-53-1 benzyl chloroformate 
• 438056-69-0 4-(4-aminophenyl)morpholin-3-one 
• 122-98-5 2-Anilinoethanol 
• 446292-04-2 4-(4-nitrophenyl)-3-morpholinone 
• 29518-11-4 4-phenylmorpholin-3-one 
• 2524-67-6 4-morpholino-4-yl-phenylamine 
• 348626-43-7 4-(4-morpholinyl)-N-benzyloxycarbonylaniline 
• 106-40-1 4-bromo-aniline 

Downstream Products

• 1117893-60-3 4-{4-[(5R)-5-(hydroxymethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one 
• 366789-02-8 Rivaroxaban 
• 1117893-61-4 R-(2-oxo-3-((4-(3-oxo-morpholinyl)phenyl)oxazolidin-5-yl))methylmethanesulfonate 
• 1313613-19-2 4-(4-((S)-5-(tert-butylaminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one 
• 1313613-22-7 4-(4-((S)-5-(tert-octylaminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one 
• 1313613-21-6 5-chloro-N-tert-butyl-N-{[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]oxazolidin-5-yl]methyl}thiophene-2-carboxamide 
• 1313613-23-8 5-chloro-N-tert-octyl-N-{[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]oxazolidin-5-yl]methyl}thiophene-2-carboxamide 
• 1313613-20-5 4-(4-((S)-5-(tert-butylaminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one methanesulfonic salt 
• 1414932-73-2 (S)-4-(4-{5-[(benzylidene-amino)-methyl]-2-oxo-oxazolidine-3-yl}-phenyl)-morpholin-3-one 
• 446292-10-0 4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one 
• 1414932-72-1 4-{4-[(S)-5-[(((4-chlorophenyl)methylene)amino)methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl}-morpholin-3-one 
• 1424942-80-2 (R)-(2-oxo-3-(4-(3-oxo-morpholino)phenyl)oxazolidin-5-yl)methyl 4-methylbenzene sulfonate 
• 1252018-26-0 4-[4-((R)-5-(iodomethyl)-2-oxo-oxazolidin-3-yl)phenyl]-morpholin-3-one 
• 1251952-73-4 4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}-morpholin-3-one p-toluenesulfonic acid salt 

Relevant articles and documents

Preparation method of rivaroxaban intermediate

The invention discloses a preparation method of a Rivaroxaban intermediate. The preparation method includes the following steps that (1) in existence of an organic lithium salt or the organic lithiumsalt and an inorganic lithium salt, a compound in a following formula I is reacted with a compound in a following formula II to obtain a compound in a following formula III; and (2) the compound in the formula III is subjected to an acidification reaction in existence of inorganic acid HX, the Rivaroxaban intermediate shown in a following formula IV is obtained, wherein R in the compound in the formula I is selected from methyl, isopropyl, normal-butyl and phenyl or benzyl, and the inorganic acid HX is selected from hydrochloric acid or sulfuric acid. The preparation method is easy to operateand high in yield, and industrial production and patent medicine quality control are convenient.

the advantage cuts down Sha Ban and intermediate preparation method

The present invention discloses a new method for preparing rivaroxaban through an intermediate represented by a formula (5), wherein the method comprises that: S-1-amino-3-chloro-2-propanol represented by a formula (2) is subjected to acylation modification to obtain a compound represented by a formula (3), the compound represented by the formula (3) reacts with 4-(3-oxomorpholineone)phenylamine formyl benzyl ester represented by a formula (4) under alkali catalysis so as to provide a structure represented by a formula (5) in a high yield manner, the intermediate is subjected to acid hydrolysis to prepare 4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl-morpholin-3-one represented by a formula (6), and the 4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl-morpholin-3-one reacts with 5-chlorothiophene-2-carbonyl chloride represented by a formula (c) to prepare the rivaroxaban. The rivaroxaban preparation method has advantages of high reaction yield, easy purification, mild reaction conditions, simple operation and the like, wherein the yield is significantly increased although acylation modification is required during the synthesis process, the purification process can be simplified, and the preparation method is suitable for industrial production.

PROCESSES FOR THE PREPARATION OF 5-CHLORO-N-({(5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL)PHENYL]-1,3-OXAZOLIDIN-5-YL}METHYL)-2-THIOPHENE-CARBOXAMIDE AND INTERMEDIATES THEREOF

The present invention relates to processes for the preparation of oxazolidinone derivatives. More particularly the present invention provides processes for the preparation of 5-chloro-N-( {(5S)-2-oxo-3-[4-(3-oxo-4-moφholinyl)phenyl]-1,3-oxazolidin-5-yl methyl)-2-thiophene-carboxamide and intennediates thereof. Where L is a leaving group like halogen atom (F, CI, Br, I) or -OS02R where R = C'-4 alkyl straight chain or branched chain, sub or unsubstituted aryl, sub or unsub aryl alkyl; with a suitable reagent to provide the compound of formula (II). The reaction step is performed by reacting the compound of formula (IV) with amine source which may be dissolved in solvent like water or alcohol. For example ammonium hydroxide.