1315571-12-0

Basic information

• Product Name: 6-chloro-2-(3-methylphenyl)benzoxazole
• Synonyms: 6-chloro-2-(3-methylphenyl)benzoxazole
• CAS NO: 1315571-12-0
• Molecular Weight: 243.692
• Mol File: 1315571-12-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 6-chloro-2-(3-methylphenyl)benzoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-2-(3-methylphenyl)benzoxazole(1315571-12-0)
• EPA Substance Registry System: 6-chloro-2-(3-methylphenyl)benzoxazole(1315571-12-0)

Safety Data

• Hazardous Substances Data: 1315571-12-0(Hazardous Substances Data)

Upstream product

• 81636-14-8 N-(4-chlorophenyl)-3-methylbenzamide 
• 3621-82-7 2,6-dichloro-1,3-benzoxazole 
• 17933-03-8 m-tolylboronic acid 
• 99-04-7 m-Toluic acid 
• 95-55-6 2-amino-phenol 
• 14625-58-2 2-(3-methylphenyl)benzoxazole 

Relevant articles and documents

Copper-catalysed intramolecular O-arylation: A simple and efficient method for benzoxazole synthesis

A wide range of 2-substituted benzoxazoles can be efficiently synthesized from N-(2-iodo-/bromo-phenyl)benzamides, and even the less reactive N-(2-chlorophenyl)benzamides, via Cu-catalysed intramolecular coupling cyclization reactions using methyl 2-methoxybenzoate as the ligand under mild reaction conditions. In addition, the benzoxazoles can be easily prepared from the primary amides coupling with o-dihalobenzenes in a single step. This journal is

Site-selective Suzuki-Miyaura reactions of 2,6-dichlorobenzoxazole

Suzuki-Miyaura reactions of 2,6-dichlorobenzoxazole provide a convenient access to arylated benzoxazoles. The reactions proceed with excellent site-selectivity in favour of position 2, due to electronic reasons.

Cyclopalladated ferrocenylimine catalyzed chlorination of 2-arylbenzoxazoles

An efficient and facile protocol for palladacycle-catalyzed chlorination of 2-arylbenzoxazoles was developed. The results represent the first examples involving the palladacycle as the catalyst for such chlorination. This chlorination was not a ligand-directed ortho-Ci-H activation, but an electrophilic substitution process at the para-position of the nitrogen atom in the benzo ring of benzoxazole moiety, the regiochemistry of which had been confirmed by HMBC spectral analysis. The catalytic system could tolerate various halogen atoms, such as F, Cl and Br, affording the corresponding products in moderate to excellent yields.