13168-11-1 Usage
Description
α-D-Glucuronic acid-1-phosphate is a key intermediate in the biosynthesis of glycosaminoglycans and plays a crucial role in the metabolism of various substances in the body. It is a derivative of glucose, with a phosphate group attached to the first carbon atom and a carboxylic acid group at the sixth carbon atom.
Uses
Used in Biochemical Research:
α-D-Glucuronic acid-1-phosphate is used as a reactant in exploiting the reversibility of natural product glycosyltransferase-catalyzed reactions. This allows for the synthesis of various glycosaminoglycans and other complex carbohydrates, which are essential for numerous biological processes.
Used in Drug Metabolism:
α-D-Glucuronic acid-1-phosphate plays a vital role in the metabolism of drugs and other xenobiotics. It is involved in the glucuronidation process, where drugs and toxins are conjugated with glucuronic acid to form water-soluble metabolites that can be easily excreted from the body. This helps in detoxification and elimination of harmful substances, thus maintaining overall health.
Used in the Synthesis of Glycosaminoglycans:
α-D-Glucuronic acid-1-phosphate is used as a building block in the synthesis of glycosaminoglycans, which are long, unbranched polysaccharides that play crucial roles in various biological processes, such as cell signaling, cell adhesion, and tissue integrity. These glycosaminoglycans are essential components of the extracellular matrix and are involved in the regulation of numerous physiological processes.
Check Digit Verification of cas no
The CAS Registry Mumber 13168-11-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,1,6 and 8 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 13168-11:
(7*1)+(6*3)+(5*1)+(4*6)+(3*8)+(2*1)+(1*1)=81
81 % 10 = 1
So 13168-11-1 is a valid CAS Registry Number.
13168-11-1Relevant articles and documents
Improved one-pot multienzyme (OPME) systems for synthesizing UDP-uronic acids and glucuronides
Muthana, Musleh M.,Qu, Jingyao,Xue, Mengyang,Klyuchnik, Timofey,Siu, Alex,Li, Yanhong,Zhang, Lei,Yu, Hai,Li, Lei,Wang, Peng G.,Chen, Xi
supporting information, p. 4595 - 4598 (2015/05/27)
Arabidopsis thaliana glucuronokinase (AtGlcAK) was cloned and shown to be able to use various uronic acids as substrates to produce the corresponding uronic acid-1-phosphates. AtGlcAK or Bifidobacterium infantis galactokinase (BiGalK) was used with a UDP-sugar pyrophosphorylase, an inorganic pyrophosphatase, with or without a glycosyltransferase for highly efficient synthesis of UDP-uronic acids and glucuronides. These improved cost-effective one-pot multienzyme (OPME) systems avoid the use of nicotinamide adenine dinucleotide (NAD+)-cofactor in dehydrogenase-dependent UDP-glucuronic acid production processes and can be broadly applied for synthesizing various glucuronic acid-containing molecules. This journal is
Process for selective oxidation of primary alcohols
-
, (2008/06/13)
Primary alcohols, especially in carbohydrates, can be selectively oxidized to aldehydes and carboxylic acids in a low-halogen process by using a peracid in the presence of a catalytic amount of a di-tertiary-alkyl nitroxyl (TEMPO) and a catalytic amount of halide. The halide is preferably bromide and the process can be carried out at nearly neutral to moderately alkaline pH (5-11). The peracid can be produced or regenerated by means of hydrogen peroxide or oxygen. The process is advantageous for producing uronic acids and for introducing aldehyde groups which are suitable for crosslinking and derivatization.
