131748-14-6

Basic information

• Product Name: 2-TRIFLUOROMETHYL-4-CHLOROPYRIDINE
• Synonyms: 2-TRIFLUOROMETHYL-4-CHLOROPYRIDINE;4-CHLORO-2-(TRIFLUOROMETHYL)PYRIDINE;4-Chloro-2-(TrifluoroMeth;4-Chloro-alpha,alpha,alpha-trifluoro-2-picoline;2-Trifluoromethyl-4-Chloropyridine(WX636118)
• CAS NO: 131748-14-6
• Molecular Formula: C₆H₃ClF₃N
• Molecular Weight: 181.54
• EINECS: 1312995-182-4
• Product Categories: Fluorine series;alkyl chloride
• Mol File: 131748-14-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 137.403 °C at 760 mmHg
• Flash Point: 36.9 °C
• Appearance: Colorless/Liquid
• Density: 1.417
• Vapor Pressure: 8.756mmHg at 25°C
• Refractive Index: 1.447
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -1.29±0.10(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 2-TRIFLUOROMETHYL-4-CHLOROPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-TRIFLUOROMETHYL-4-CHLOROPYRIDINE(131748-14-6)
• EPA Substance Registry System: 2-TRIFLUOROMETHYL-4-CHLOROPYRIDINE(131748-14-6)

Safety Data

• Hazard Codes: Xi,T
• Statements: 25-36
• Safety Statements: 26-45
• RIDADR: UN2811
• HazardClass: 6.1
• Hazardous Substances Data: 131748-14-6(Hazardous Substances Data)

Usage

Description

2-TRIFLUOROMETHYL-4-CHLOROPYRIDINE is an organic compound characterized by the presence of a pyridine ring with a trifluoromethyl group at the 2nd position and a chlorine atom at the 4th position. It is a derivative of chloro(trifluoromethyl)pyridines, which are known for their unique chemical properties and potential applications in various fields.

Uses

Used in Chemical Synthesis:
2-TRIFLUOROMETHYL-4-CHLOROPYRIDINE is used as a model substrate for regioexhaustive functionalization in chemical synthesis. Its unique structure allows for selective modification and functionalization, making it a valuable compound for the development of new chemical entities and materials.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 2-TRIFLUOROMETHYL-4-CHLOROPYRIDINE is used as a starting material or intermediate for the synthesis of various drug candidates. Its specific functional groups and structural features can be exploited to design and develop novel therapeutic agents with potential applications in treating various diseases and medical conditions.
Used in Material Science:
2-TRIFLUOROMETHYL-4-CHLOROPYRIDINE can also be utilized in the field of material science, where it may serve as a building block for the development of advanced materials with specific properties. Its unique chemical structure can contribute to the creation of materials with enhanced performance characteristics, such as improved stability, reactivity, or selectivity.

InChI:InChI=1/C6H3ClF3N/c7-4-1-2-11-5(3-4)6(8,9)10/h1-3H

Upstream product

• 170886-13-2 4-hydroxy-2-trifluoromethylpyridine 

Downstream Products

• 131747-41-6 2-(trifluoromethyl)-4-pyridinecarboxylic acid 
• 108338-20-1 2-(trifluoromethyl)pyridine-4-carbaldehyde 
• 131747-61-0 <2-(trifluoromethyl)pyridin-4-yl>methanol 
• 108338-12-1 2,6-Dimethyl-4-(2-trifluoromethyl-4-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-(N-benzyl-N-methylamino)ethyl ester 5-methyl ester 
• 1354355-58-0 (4-(2-(trifluoromethyl)pyridin-4-yl)phenyl)methanamine 
• 1313399-63-1 N-tert-butyloxycarbonyl-protected 2-[4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]ethanamine 
• 1448541-31-8 methyl 2-[3-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]acetate 
• 1448545-15-0 ethyl 4-ethyl-2-methyl-6-[[2-[4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]acetyl]amino]pyrimidine-5-carboxylate 
• 1448541-32-9 2-[3-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]acetamide 
• 1448594-73-7 2-[4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]ethanamine hydrochloride 
• 1449243-22-4 C₁₉H₂₀F₄N₂O₃ 
• 1448541-18-1 N-(2-methylpyrimidin-4-yl)-2-[3-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]acetamide 
• 1313399-64-2 2-[4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]ethanamine 
• 1448545-14-9 6-(1-fluoroethyl)-N-[2-[2-fluoro-4-[[2-(trifluoromethyl)-4-pyridyl]oxy]phenyl]ethyl]-2-methyl-pyrimidin-4-amine 

Relevant articles and documents

PESTICIDALLY ACTIVE HETEROCYCLIC DERIVATIVES WITH SULFUR CONTAINING SUBSTITUENTS

Compounds of formula (I), wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides and can be prepared in a manner known per se.

PROCESS FOR THE PREPARATION OF 2-TRIFLUOROMETHYL ISONICOTINIC ACID AND ESTERS

The invention relates to a novel process for the preparation of 2- trifluoromethyl isonicotinic acid and esters of the formula I which involves a palladium catalysed carbonylation or cyanation step wherein R1 is hydrogen or Q1-6-alkyl. The 2-trifluoromethyl isonicotinic acid and esters of the formula I are versatile intermediates for the preparation of active pharmaceutical and agrochemical agents such as for instance TAAR 1 agonists of the formula III.