13177-82-7Relevant articles and documents
Some Novel Reactions of 1,3-Dimethyluracils. II. Studies on New Stable Pyrimidine Ring-Opened Compounds
Kawahara, Norio,Itoh, Tsuneo,Ogura, Haruo,Watanabe, Kyoichi A.
, p. 63 - 66 (2007/10/02)
N,N'-Dialkyl-N-ureas (3) were synthesized by coupling of 1,3-dialkyl-6-(N-substituted)aminouracils (2) and dimethyl acetylenedicarboxylate (DMAD).Compounds (3) are stable crystalline materials at room temperature, but on heating in DMF, they undergo cyclization, giving rise to the pyridopyrimidine derivatives.These compounds were characterized by 1H-nuclear magnetic resonance (NMR), 13C-NMR, mass spectral and elemental analyses.