131926-36-8

Basic information

• Product Name: 1H-Isoindole-1,3(2H)-dione,2-(hexahydro-2,7-dioxo-1H-azepin-3-yl)-, (S)- (9CI)
• CAS NO: 131926-36-8
• Molecular Formula: C14H12 N2 O4
• Molecular Weight: 272.26
• Mol File: 131926-36-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1H-Isoindole-1,3(2H)-dione,2-(hexahydro-2,7-dioxo-1H-azepin-3-yl)-, (S)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Isoindole-1,3(2H)-dione,2-(hexahydro-2,7-dioxo-1H-azepin-3-yl)-, (S)- (9CI)(131926-36-8)
• EPA Substance Registry System: 1H-Isoindole-1,3(2H)-dione,2-(hexahydro-2,7-dioxo-1H-azepin-3-yl)-, (S)- (9CI)(131926-36-8)

Safety Data

• Hazardous Substances Data: 131926-36-8(Hazardous Substances Data)

Upstream product

• 671-42-1 D(+)-α-Amino-ε-caprolactam 
• 21568-87-6 L(-)-α-Amino-ε-caprolactam 

Relevant articles and documents

Synthesis, central nervous system activity and teratogenicity of a homothalidomide

The optical isomers of α-phthalimidoadipinimide (1) were synthesized by a route based on D(+)- and L(-)-amino-ε-caprolactam (5) as synthon. The isomers of 1 were obtained in high yields by treating D(+)- and L(-)-amino-ε-caprolactam (5) with N-carboethoxyphthalimide (4), followed by oxidation with benzeneseleninic anhydride (7). The teratogenic potency of both isomers of 1 was studied by the HET-(Hen's Egg Test); 1 caused distinctly lower teratogenic effects in contrast to thalidomide (2). D(-)-1 and L(+)-1 showed sedative effects with a lower activity than 2. Both are more stable in alkaline solution at the same time with a smaller tendency for racemization.