132089-42-0

Basic information

• Product Name: 2-(4-FLUORO-PHENYL)-OXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER
• Synonyms: 2-(4-FLUORO-PHENYL)-OXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER;2-(4-fluorophenyl)-4-Oxazolecarboxylic acid ethyl ester;4-Oxazolecarboxylicacid, 2-(4-fluorophenyl)-, ethyl ester;ETHYL 2-(4-FLUOROPHENYL)OXAZOLE-4-CARBOXYLATE
• CAS NO: 132089-42-0
• Molecular Formula: C₁₂H₁₀FNO₃
• Molecular Weight: 235.21
• Mol File: 132089-42-0.mol
• Article Data: 7

Chemical Properties

• Melting Point: 102-104 °C
• Boiling Point: 335.1±48.0 °C(Predicted)
• Appearance: /
• Density: 1.242±0.06 g/cm3(Predicted)
• PKA: -2.05±0.10(Predicted)
• CAS DataBase Reference: 2-(4-FLUORO-PHENYL)-OXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-FLUORO-PHENYL)-OXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER(132089-42-0)
• EPA Substance Registry System: 2-(4-FLUORO-PHENYL)-OXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER(132089-42-0)

Safety Data

• Hazardous Substances Data: 132089-42-0(Hazardous Substances Data)

Usage

Description

2-(4-Fluoro-phenyl)-oxazole-4-carboxylic acid ethyl ester is a chemical compound that is used in the pharmaceutical industry. It is an ethyl ester derivative of oxazole-4-carboxylic acid, a heterocyclic compound commonly found in pharmaceuticals. 2-(4-FLUORO-PHENYL)-OXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER features a fluorine-substituted phenyl group, which contributes to its potential for developing new drugs with unique biological activities.
Used in Pharmaceutical Industry:
2-(4-Fluoro-phenyl)-oxazole-4-carboxylic acid ethyl ester is used as a building block for the synthesis of various pharmaceutical agents. Its incorporation into drug molecules can enhance their biological activity and selectivity, making it a valuable component in drug discovery and development processes. The presence of the fluorine atom and the heterocyclic oxazole ring may confer specific properties to the resulting pharmaceuticals, such as improved pharmacokinetics or targeted action against certain biological pathways.

Upstream product

• 23012-14-8 oxazole-4-carboxylic acid ethyl ester 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 70-23-5 ethyl Bromopyruvate 
• 824-75-9 p-fluorobenzamide 
• 1765-93-1 4-fluoroboronic acid 
• 460081-20-3 2-bromo-4-(ethoxycarbonyl)-1,3-oxazol-5-ylium 
• 177760-52-0 ethyl 2-aminooxazole-4-carboxylate 
• 460081-18-9 ethyl 2-chloro-1,3-oxazole-4-carboxylate 

Downstream Products

• 1582221-30-4 ethyl 2-(4-fluorophenyl)-5-phenyloxazole-4-carboxylate 
• 148563-23-9 2-(4-fluorophenyl)oxazolo[4,5-c]quinolin-4(5H)-one 

Relevant articles and documents

Rational Design, Synthesis and Evaluation of Oxazolo[4,5-c]-quinolinone Analogs as Novel Interleukin-33 Inhibitors

Interleukin-33 (IL-33) is an epithelial-derived cytokine that plays an important role in immune-mediated diseases such as asthma, atopic dermatitis, and rheumatoid arthritis. Although IL-33 is considered a potential target for the treatment of allergy-rel

INHIBITORS OF HISTONE DEACETYLASE USEFUL FOR THE TREATMENT OR PREVENTION OF HIV INFECTION

The present invention relates to Compounds of Formula (I): Formula (I) and pharmaceutically acceptable salts or prodrug thereof, wherein R1, R2, R3, Ra, Rb, A and B are as defined herein. The present invention also relates to compositions comprising at least one compound of Formula (I), and methods of using the compounds of Formula (I) for treating or preventing HIV infection in a subject.

Design, synthesis and biological evaluation of 2,4-disubstituted oxazole derivatives as potential PDE4 inhibitors

In this study, a series of pyrazole derivatives containing 4-phenyl-2-oxazole moiety were designed and synthesized in a concise way, some of which exhibited considerable inhibitory activity against PDE4B and blockade of LPS-induced TNF-α release. Compound