132123-39-8Relevant articles and documents
Suzuki cross-coupling reactions of aryl chlorides using [Cl 2Pd(COD)]/piperazine derivative under microwave conditions
Zhou, Zhong-Gao,Shi, Ji-Cheng,Hu, Qiao-Sheng,Xie, Yong-Rong,Du, Zi-Yi,Zhang, Shi-Yong
, p. 616 - 619 (2011)
A new strategy to significantly improve the efficiency of Suzuki reactions was achieved under microwave irradiation. [Cl2Pd(COD)]/piperazine derivative 1 catalyzed aryl chlorides with phenylboronic acid in methanol (50%) affording excellent yields under aerobic conditions. Application of this strategy to the synthesis of liquid crystal material is also described.
An aerobic and very fast Pd/C-catalyzed ligand-free and aqueous Suzuki reaction under mild conditions
Liu, Chun,Rao, Xiaofeng,Zhang, Yixia,Li, Xinmin,Qiu, Jieshan,Jin, Zilin
supporting information, p. 4345 - 4350 (2013/07/26)
An aerobic, ligand-free Suzuki reaction catalyzed by Pd/C in aqueous media has been developed. This method is a very simple, efficient and mild protocol for the cross-coupling of aryl bromides with arylboronic acids, and the reactions proceeded smoothly in excellent yields within short reaction times. Control experiments demonstrated that the Pd/C-catalyzed Suzuki reaction was much quicker when performed in air or oxygen than in nitrogen. Furthermore, this protocol could be used for the synthesis of fluorinated liquid-crystalline compounds. The Pd/C catalyst could be recovered and recycled efficiently at least ten times without significant loss of catalytic activity. Copyright