13230-84-7

Basic information

• Product Name: AcetaMide, 2-chloro-N-Methyl-N-(2-phenylethyl)-
• Synonyms: AcetaMide, 2-chloro-N-Methyl-N-(2-phenylethyl)-;2-chloro-N-methyl-N-(2-phenylethyl)acetamide
• CAS NO: 13230-84-7
• Molecular Formula: C₁₁H₁₄ClNO
• Molecular Weight: 211.68796
• Mol File: 13230-84-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 330°C at 760 mmHg
• Flash Point: 153.4°C
• Appearance: /
• Density: 1.128g/cm³
• Vapor Pressure: 0.000171mmHg at 25°C
• Refractive Index: 1.534
• CAS DataBase Reference: AcetaMide, 2-chloro-N-Methyl-N-(2-phenylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: AcetaMide, 2-chloro-N-Methyl-N-(2-phenylethyl)-(13230-84-7)
• EPA Substance Registry System: AcetaMide, 2-chloro-N-Methyl-N-(2-phenylethyl)-(13230-84-7)

Safety Data

• Hazardous Substances Data: 13230-84-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H14ClNO/c1-13(11(14)9-12)8-7-10-5-3-2-4-6-10/h2-6H,7-9H2,1H3

Upstream product

• 79-04-9 chloroacetyl chloride 
• 589-08-2 N-Methyl-N-phenethylamine 
• 103-63-9 1-phenyl-2-bromoethane 

Downstream Products

• 73644-95-8 1,2,4,5-tetrahydro-3-methyl-3H-3-benzazepin-2-one 
• 253324-91-3 1-amino-3-methyl-1H,4H,5H-benzo-[d]azaperhydroepin-2-one 
• 253324-92-4 (1S)-1-amino-3-methyl-1H,4H,5H-benzo[d]azaperhydroepin-2-one 
• 253324-92-4 (1R)-1-amino-3-methyl-1H,4H,5H-benzo[d]azaperhydroepin-2-one 
• 425663-71-4 (1S)-1-amino-3-methyl-1H,4H,5H-benzo[d]azaperhydroepin-2-one hydrochloride 
• 425386-58-9 (1S)-1-amino-3-methyl-1H,4H,5H-benzo[d]azaperhydroepin-2-one di-p-toluoyl-L-tartrate 
• 73645-05-3 1,2,4,5-tetrahydro-1-cyclohexyl-3-methyl-3H-3-benzazepin-2-one 
• 73645-01-9 1,2,4,5-tetrahydro-1-benzyl-3-methyl-3H-3-benzazepin-2-one 
• 73645-03-1 1,2,4,5-tetrahydro-1-(2,3-dimethoxybenzyl)-3-methyl-3H-3-benzazepin-2-one 

Relevant articles and documents

Classical and dynamic resolution of 1-amino-3-methyl-1,3,4,5- tetrahydrobenzo[d]azepin-2-one

Two efficient production processes of enantioenriched 1-amino-3-methyl-1,3, 4,5-tetrahydro-benzo[d]azepin-2-one 1 were achieved using the readily available starting materials. A key step in the methodologies is a classical resolution or a dynamic resolution that provides excellent chemical (>80%) yields and enantiomeric excesses (>99.8% ee). The classical resolution was developed on a preparative scale while the dynamic resolution was implemented on a pilot plant scale.

BENZOLACTAMS-1. ALKYLATION OF 1,2,4,5-TETRAHYDRO-3-METHYL-3H-3-BENZAZEPIN-2-ONE WITH SODIUM HYDRIDE AND ALKYL HALIDE

Alkylation of 1,2,4,5-tetrahydro-3-methyl-3H-3-benzazepin-2-one 1a with various halides and sodium hydride in tetrahydrofuran-dimethylformamide solvent system was studied.Primary halides predominantly provided the 1-mono-substituted products, such as alkyl (2a-g,p,q), allyl (2j,k), propargyl (2l) and benzyl (2m-o) derivatives, in satisfactory yields, and secondary halides resulted in lower yields (2h,i) than primary halides.In attempted dialkylations with ω,ω'-dibromoalkanes, 5- and 6-membered spiro products (4c,d) were obtained by this method.The Michael type addition reaction was also studied and it was found that acrylic acid esters gave the corresponding adducts (2p,q).