132363-86-1Relevant articles and documents
Convenient synthesis of trichloromethyldihydroquinolines and -isoquinolines
Grignon-Dubois,Diaba,Grellier-Marly
, p. 800 - 804 (1994)
The reaction of a series of N-alkylquinolinium and -isoquinolinium iodides towards sodium trichloroacetate in acetonitrile has been investigated under reflux or ultrasonication. In all cases, addition of trichloromethyl anion was observed, and trichloromethyldihydroquinoline or -isoquinoline derivatives were obtained in good yields. Depending on the activation process, addition occurred at the 2- or the 4-position with quinolines and at the 1-position with isoquinolines.