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132376-92-2

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132376-92-2 Usage

Description

[5',5''-2H2]THYMIDINE, also known as Thymidine-5',5''-D2, is a deuterated labeled version of Thymidine (T412000), which is a fundamental component of deoxyribonucleic acid (DNA). [5',5''-2H2]THYMIDINE is characterized by the presence of two deuterium atoms (2H) at the 5' and 5'' positions, which distinguishes it from the naturally occurring Thymidine.

Uses

Used in Biochemical Research:
[5',5''-2H2]THYMIDINE is used as a labeled compound in biochemical research for studying the synthesis, replication, and repair mechanisms of DNA. The incorporation of deuterium atoms allows researchers to track and analyze the behavior of this nucleoside within biological systems, providing valuable insights into DNA-related processes.
Used in Pharmaceutical Development:
In the pharmaceutical industry, [5',5''-2H2]THYMIDINE serves as a key component in the development of drugs targeting DNA metabolism. Its unique properties enable the investigation of drug interactions with DNA, potentially leading to the discovery of novel therapeutic agents for various diseases, including cancer and genetic disorders.
Used in Diagnostic Applications:
[5',5''-2H2]THYMIDINE is utilized in diagnostic applications, such as the detection and quantification of DNA in various samples. The deuterated labeled Thymidine can be employed in techniques like mass spectrometry or nuclear magnetic resonance (NMR) to accurately measure DNA content, aiding in the diagnosis of diseases and monitoring treatment efficacy.
Used in Forensic Science:
In forensic science, [5',5''-2H2]THYMIDINE plays a crucial role in DNA analysis for criminal investigations. The labeled Thymidine can be used to differentiate between samples, ensuring accurate identification and helping to solve crimes by providing reliable DNA evidence.

Check Digit Verification of cas no

The CAS Registry Mumber 132376-92-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,2,3,7 and 6 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 132376-92:
(8*1)+(7*3)+(6*2)+(5*3)+(4*7)+(3*6)+(2*9)+(1*2)=122
122 % 10 = 2
So 132376-92-2 is a valid CAS Registry Number.

132376-92-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name [5',5''-2H2]THYMIDINE

1.2 Other means of identification

Product number -
Other names diethyl 3,3'-diethyl-4,4'-dimethyl-2,2'-dipyrrylmethane-5,5'-dicarboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:132376-92-2 SDS

132376-92-2Upstream product

132376-92-2Downstream Products

132376-92-2Relevant articles and documents

Isotope effects on the sequence-specific cleavage of DNA by neocarzinostatin: Kinetic partitioning between 4'- and 5'-hydrogen abstraction at unique thymidine sites

Frank,Worth Jr.,Christner,Kozarich,Stubbe,Kappen,Goldberg

, p. 2271 - 2275 (1991)

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