13264-88-5

Basic information

• Product Name: (S)-(-)-2-methylpiperazine dihydrochloride
• CAS NO: 13264-88-5
• Molecular Weight: 173.086
• Mol File: 13264-88-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (S)-(-)-2-methylpiperazine dihydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(-)-2-methylpiperazine dihydrochloride(13264-88-5)
• EPA Substance Registry System: (S)-(-)-2-methylpiperazine dihydrochloride(13264-88-5)

Safety Data

• Hazardous Substances Data: 13264-88-5(Hazardous Substances Data)

Upstream product

• 107-21-1 ethylene glycol 
• 78-90-0 1,2-diaminopropan 
• 57-55-6 propylene glycol 
• 107-15-3 ethylenediamine 
• 51514-17-1 methyl (2S)-2-[(aminoacetyl)amino]propanoate 
• 3695-73-6 glycyl-L-alanine 
• 4526-77-6 (S)-3-methyl-2,5-piperazinedione 

Downstream Products

• 75336-86-6 (2R)-methylpiperazine 
• 160738-57-8 gatifloxacin 
• 130982-86-4 (R)-(+)-temafloxacin 
• 130982-85-3 (S)-(-)-temafloxacin 

Relevant articles and documents

METHOD FOR PRODUCING OPTICALLY ACTIVE 2-METHYLPIPERAZINE

PROBLEM TO BE SOLVED: To provide a method capable of industrially obtaining an optically active 2-methylpiperazine which is easy in handling and has good properties, instead of the isolation method of an optically active 2-methylpiperazine by conventional distillation. SOLUTION: There is provided a method for producing an optically active 2-methylpiperazine by adding a solvent to a solution of an optically active 2-methylpiperazine, followed by solvent substitution and crystallization to obtain crystals of the optically active 2-methylpiperazine. SELECTED DRAWING: None COPYRIGHT: (C)2016,JPOandINPIT

The Absolute Configurations of (+)- and (-)-2-Methylpiperazines and their N-Methyl Derivatives.

S(-)-2-Methylpiperazinium dichloride was prepared by reduction of S(-)-3-methyl-2,5-dioxopiperazine (from glycyl-S-alanine) which established its absolute configuration.This dichloride and its enantiomer, R(+)-2-methylpiperazinium dichloride, were obtained in less optically pure forms by recrystallization of the diastereomeric RS-2-methylpiperazinium 2R,3R-di-O-benzoyltartrate salts followed by decomposition with a base.They were converted into S(+)- and R(-)-1,2,4-trimethylpiperazinium dichloride, S(+)- and R(-)-1,2,4,4-tetramethylpiperazinium iodide and S(+)- and R(-)-1,1,2,4,4-pentamethylpiperazinium diiodide.