132666-67-2

Basic information

• Product Name: 2-(R)-CARBOETHOXY-4-(R)-HYDROXYPYRROLIDINE
• Synonyms: 2-(R)-CARBOETHOXY-4-(R)-HYDROXYPYRROLIDINE;D-Proline, 4-hydroxy-, ethyl ester, cis- (9CI)
• CAS NO: 132666-67-2
• Molecular Formula: C₇H₁₃NO₃
• Molecular Weight: 159.18
• Product Categories: PYRROLE;CARBOXYLICESTER;chiral;Miscellaneous
• Mol File: 132666-67-2.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 262.3 °C at 760 mmHg
• Flash Point: 112.4 °C
• Appearance: /
• Density: 1.171g/cm³
• CAS DataBase Reference: 2-(R)-CARBOETHOXY-4-(R)-HYDROXYPYRROLIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(R)-CARBOETHOXY-4-(R)-HYDROXYPYRROLIDINE(132666-67-2)
• EPA Substance Registry System: 2-(R)-CARBOETHOXY-4-(R)-HYDROXYPYRROLIDINE(132666-67-2)

Safety Data

• Hazardous Substances Data: 132666-67-2(Hazardous Substances Data)

Usage

General Description

2-(R)-carboethoxy-4-(R)-hydroxypyrrolidine, also known as Ropinirole, is a synthetic compound used as a dopamine agonist for the treatment of Parkinson's disease and restless legs syndrome (RLS). It works by stimulating dopamine receptors in the brain, helping to improve muscle control and reduce the symptoms of these conditions. Ropinirole is available in various forms, including tablets and extended-release capsules, and is typically taken orally. It may cause side effects such as dizziness, nausea, and drowsiness, and may interact with other medications, so it should be used with caution and under the guidance of a healthcare professional.

Upstream product

• 64-17-5 ethanol 
• 51-35-4 4R-4-hydroxyproline 
• 2584-71-6 cis-hydroxy-D-proline 
• 51-35-4 4-hydroxyproline 
• 77449-94-6 (2R,4R)-4-hydroxypyrrolidine-2-carboxylic acid hydrochloride 
• 171192-72-6 (2R,4R)-ethyl N¹-benzyl-4-hydroxypyrrolidine-2-carboxylate 

Downstream Products

• 116143-05-6 allo-1-(4-tolylsulfonyl)-4-<<(4-methylphenyl)sulfonyl>oxy>-D-proline ethyl ester 
• 116143-07-8 1-(4-tolylsulfonyl)-4-hydroxy-D-proline ethyl ester 
• 171192-72-6 (2R,4R)-ethyl N¹-benzyl-4-hydroxypyrrolidine-2-carboxylate 
• 911697-24-0 (2R,4S)-4-Amino-1-benzyl-pyrrolidine-2,4-dicarboxylic acid dimethyl ester 
• 911697-28-4 (2R,4S)-1-Benzyl-4-tert-butoxycarbonylamino-pyrrolidine-2,4-dicarboxylic acid dimethyl ester 
• 911697-25-1 (2R,4R)-4-amino-1-benzyl-pyrrolidine-2,4-dicarboxylic acid dimethyl ester 
• 238753-26-9 (2R,4R)-1-benzyl-4-tert-butoxycarbonylamino-pyrrolidine-2,4-dicarboxylic acid dimethyl ester 
• 502442-65-1 ethyl (2R,4R)-N-tert-butyloxycarbonyl-4-tert-butyldiphenylsiloxyprolinate 
• 169209-63-6 (2R,4R)-4-amino-4-carboxyproline 
• 171336-79-1 (2R,4S)-4-amino-4-carboxyproline 
• 174266-80-9 diethyl (2R,4R)-1-benzyl-4-aminopyrrolidine-2,4-dicarboxylate 
• 178963-35-4 (2R,4S)-4-Amino-1-benzyl-pyrrolidine-2,4-dicarboxylic acid diethyl ester 
• 174266-81-0 (2R,4R) diethyl-1-benzyl-4-(tert-butyloxycarbonylamino) pyrrolidine-2,4-dicarboxylate 
• 179030-55-8 (2R,4S)-1-Benzyl-4-tert-butoxycarbonylamino-pyrrolidine-2,4-dicarboxylic acid diethyl ester 

Relevant articles and documents

A short diastereoselective synthesis of cis-(2S,4S) and cis-(2R,4R)-4-hydroxyprolines

A concise synthesis of (2R,4R)-4-hydroxyproline (1) and (2S,4S)-4-hydroxyproline (2) has been developed in enantiomerically pure form from commercially available starting materials with excellent diastereoselectivity. The tightly bound chelation controlled transition state formed during the 5-exo-tet ring closure reaction is assumed to be the origin of high diastereoselectivity.

FUSED PYRAZINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES

Novel[1.2.4]triazolo[1,5-a]pyrazine and imidazo[1,2-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, and others.

Design and synthesis of APTCs (aminopyrrolidinetricarboxylic acids): Identification of a new group III metabotropic glutamate receptor selective agonist

A new family of mGlu receptor orthosteric ligands called APTCs was designed and synthesized using a parallel chemistry approach. Amongst 65 molecules tested on mGlu4, mGlu6 and mGlu8 subtypes, (2S,4S)-4-amino-1-[(E)-3-carboxyacryloyl]pyrrolidine-2,4-dicar