132666-79-6

Basic information

• Product Name: N‐benzyl‐4‐methylthiazol‐2‐amine
• Synonyms: N‐benzyl‐4‐methylthiazol‐2‐amine
• CAS NO: 132666-79-6
• Molecular Weight: 204.296
• Mol File: 132666-79-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N‐benzyl‐4‐methylthiazol‐2‐amine(CAS DataBase Reference)
• NIST Chemistry Reference: N‐benzyl‐4‐methylthiazol‐2‐amine(132666-79-6)
• EPA Substance Registry System: N‐benzyl‐4‐methylthiazol‐2‐amine(132666-79-6)

Safety Data

• Hazardous Substances Data: 132666-79-6(Hazardous Substances Data)

Upstream product

• 78-95-5 chloroacetone 
• 621-83-0 N-benzylthiourea 
• 67-64-1 acetone 
• 1603-91-4 4-methylthiazol-2-ylamine 
• 100-52-7 benzaldehyde 
• 1666-17-7 benzaldehyde p-toluenesulfonylhydrazone 
• 333-20-0 potassium thioacyanate 
• 2182-52-7 benzylamine acetic acid 
• 14779-10-3 μ-disulfido-1,2-diimido-dicarbonic acid bis-benzylamide; dihydrobromide 
• 100-44-7 benzyl chloride 

Downstream Products

• 132666-75-2 Benzyl-[4-methyl-5-(2,4,6-trinitro-phenyl)-thiazol-2-yl]-amine 

Relevant articles and documents

Synthetic method for N-alkyl(benzo)thiazole

The invention provides a synthetic method for N-alkyl(benzo)thiazole. The synthetic method comprises the following steps: putting 0.4-0.8 mmol of a carbonyl compound, 0.4-0.8 mmol of p-toluenesulfonylhydrazide and 4-10 mL of a solvent in a flask and carrying out a reaction at 30 DEG C to 80 DEG C for 1 to 3 h; adding 0.4 mmol of 2-aminothiazole, 0.4-0.8 mmol of metal copper salt and 0.4-1.2 mmolof an alkali substance into the above reaction system, carrying out heating to 100 DEG C to 150 DEG C, and continuing the reaction for 2 h to 5 h; terminating the reaction to obtain a reaction productA; and subjecting the product A to purification and impurity separation so as to obtain pure N-alkyl(benzo)thiazole. According to the invention, the intermediate sulfonyl hydrazone is prepared from the carbonyl compound and sulfonyl hydrazide, and reacts with a 2-aminothiazole substance in the presence of a catalyst and under alkali conditions to obtain N-alkyl(benzo)thiazole. The synthetic method of the invention has the advantages of simple operation, low cost, high product yield and wide application range of a substrate. At the same time, the established method can also realize the synthesis of the anti-inflammatory drug fanetizole, and thus has high practical value.

One pot synthesis using supported reagents system KSCN/SiO 2-RNH3OAc/Al2O3: Synthesis of 2-aminothiazoles and N-allylthioureas

A simple and efficient method has been developed for the synthesis of 2-aminothiazoles and N-allylthioureas from commercially available materials in one pot by using a supported reagents system, KSCN/SiO2-RNH 3OAc/Al2O3, in which α-halo ketone reacts first KSCN/SiO2 and the product, α-thiocyanatoketone, reacts with RNH3OAc/Al2O3 to give the final product, 2-aminothiazoles, in good yield and allyl bromide reacts with KSCN/SiO 2 and the product, allyl isothiocyanate, reacts with RNH 3OAc/Al2O3 to give N-allylthiourea.