1327336-78-6

Basic information

• Product Name: C₂₉H₃₇BrN₄O₄
• Synonyms: C₂₉H₃₇BrN₄O₄
• CAS NO: 1327336-78-6
• Molecular Weight: 585.541
• Mol File: 1327336-78-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₉H₃₇BrN₄O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₉H₃₇BrN₄O₄(1327336-78-6)
• EPA Substance Registry System: C₂₉H₃₇BrN₄O₄(1327336-78-6)

Safety Data

• Hazardous Substances Data: 1327336-78-6(Hazardous Substances Data)

Upstream product

• 1301177-22-9 C₂₁H₂₁BrN₂O 
• 1301177-24-1 C₂₁H₂₃BrN₂O₃ 
• 1301177-26-3 C₂₀H₁₉BrN₂O₂ 
• 1313227-33-6 C₂₀H₁₉BrN₂O₃ 
• 176982-57-3 (3-amino-1(S)-methylpropyl)carbamic acid, 1,1-dimethylethyl ester 

Downstream Products

• 1327336-85-5 C₂₄H₂₉BrN₄O₂ 

Relevant articles and documents

Macrocyclic lactams as potent Hsp90 inhibitors with excellent tumor exposure and extended biomarker activity

A novel series of macrocyclic ortho-aminobenzamide Hsp90 inhibitors is reported. In continuation of our research in this area, macrocyclic amides and lactams were explored to reduce the risk of hERG liabilities. This effort culminated in the discovery of compound 38, which showed a favorable in vitro profile, and efficiently suppressed proliferation of several relevant cell lines. This compound showed prolonged Hsp90-inhibitory activity at least 24 h post-administration, consistent with elevated and prolonged exposure in the tumor.