13298-76-5Relevant articles and documents
A convenient preparation of diazo carbonyl compounds under tri-phase phase-transfer catalysis conditions
Madan Kumar
, p. 2121 - 2127 (1991)
A simple and convenient one-pot preparation method for pure diazo carbonyl compounds under tri-phase phase-transfer catalysis conditions is described.
Cobalt(II)-catalyzed asymmetric olefin cyclopropanation with α-ketodiazoacetates
Xu, Xue,Zhu, Shifa,Cui, Xin,Wojtas, Lukasz,Zhang, X. Peter
, (2013)
Porphyrin and Co.: The cobalt(II) complex 1 is an effective metalloradical catalyst for cyclopropanation of alkenes with α-acetodiazoacetates at room temperature to yield E-1,1-cyclopropaneketoesters in high yields with both high diastereo- and enantiosel
Exploiting the Continuous in situ Generation of Mesyl Azide for Use in a Telescoped Process
O'Mahony, Rosella M.,Lynch, Denis,Hayes, Hannah L. D.,Ní Thuama, Eilís,Donnellan, Philip,Jones, Roderick C.,Glennon, Brian,Collins, Stuart G.,Maguire, Anita R.
, p. 6533 - 6539 (2017)
The hazardous diazo transfer reagent mesyl azide has been safely generated and used in situ for continuous diazo transfer as part of an integrated synthetic process with an embedded safety quench. Diazo transfer to β-keto esters and a β-ketosulfone was successful. In-line phase separation, by means of a continuous liquid–liquid separator, enabled direct telescoping with a thermal Wolff rearrangement.
Catalytic Ring Expansion of Activated Heteroarenes Enabled by Regioselective Dearomatization
Kim, Jiyoung,Yoo, Eun Jeong
, p. 4256 - 4260 (2021)
Catalytic ring expansion of activated heteroarenes through 1,4-dearomative addition of diazoacetates was established for the construction of various fused azepines by an elaborate control of the reaction kinetics at each step. The use of a silver catalyst was essential to drive the overall reaction for generating the desired seven-membered azepines. Because of the excellent substrate scope and selectivity, the developed methodology presents an innovative approach for the synthesis of multifused azepines, which are biologically relevant molecules.
Construction of enantiomerically enriched diazo compounds using diazo esters as nucleophiles: Chiral Lewis base catalysis
Mao, Haibin,Lin, Aijun,Shi, Yan,Mao, Zhijie,Zhu, Xuebin,Li, Weipeng,Hu, Hongwen,Cheng, Yixiang,Zhu, Chengjian
, p. 6288 - 6292 (2013)
Amazing diazo: The title reaction leads to highly functionalized diazo compounds in good yields with excellent enantioselectivities (see scheme; Boc=tert-butoxycarbonyl). The utility of the products was demonstrated by the rapid synthesis of a number of o
Ruthenium(II)-Catalyzed Ortho-C-H Alkylation of Naphthylamines with Diazo Compounds for Synthesis of 2,2-Disubstituted π-Extended 3-Oxindoles in Water
Wang, Xiaogang,Zhang, Jin,He, Yuan,Chen, Di,Wang, Chao,Yang, Fangzhou,Wang, Weitao,Ma, Yangmin,Szostak, Michal
, p. 5187 - 5192 (2020)
Ruthenium(II)-catalyzed ortho-C-H alkylation of naphthylamines with diazo compounds for the synthesis of 2,2-disubstituted π-extended 3-oxindoles has been developed. The method represents the first example of C-H alkylation via carbenoid insertion in wate
A method for efficient synthesis of dinitrous compounds
-
Paragraph 0020-0024; 0045-0049, (2022/01/12)
The present invention discloses a method for efficiently synthesizing a diazo compound, the method of organic matter with an active methylene as a raw material,NaN3 as an auxiliary reagent for diazo transfer,CH2Cl2 as a re
Rh-Catalyzed Coupling of Acrylic/Benzoic Acids with α-Diazocarbonyl Compounds: An Alternative Route for α-Pyrones and Isocoumarins
Hong, Chao,Liu, Zhanxiang,Yu, Shuling,Zhang, Yuhong
supporting information, p. 815 - 820 (2022/02/07)
A coupling of acrylic acids/benzoic acids with α-diazocarbonyl compounds has been realized by a combined catalytic system of rhodium catalyst and Zn(OAc)2 additive. The presence of Zn(OAc)2 obviously accelerates the C(sp2)
