1331783-45-9Relevant articles and documents
Recyclable NaHSO4 catalyzed alkylation of tert-enamides with indoles or amines in water: Facile construction of pharmaceutically analogous bis-alkaloid scaffolds
Chu, Xue-Qiang,Wang, Shun-Yi,Ji, Shun-Jun
, p. 8380 - 8387 (2013/09/02)
An efficient sodium hydrogen sulfate catalyzed alkylation of indoles or amines with tertiary enamides has been accomplished in water, affording the pharmacologically and biologically active 2-oxo-1-pyrrolidine derivatives in moderate to excellent yields. The key to our success is the use of NaHSO 4 as a low loading, inexpensive, green and recyclable catalyst and the reactions could be scaled up to gram level.