133188-66-6

Basic information

• Product Name: Benzenepropanoyl chloride, 4-fluoro-
• Synonyms: Benzenepropanoyl chloride, 4-fluoro-;4-(4-fluorophenyl)butanoyl chloride
• CAS NO: 133188-66-6
• Molecular Formula: C₁₀H₁₀ClFO
• Molecular Weight: 186.6106232
• Mol File: 133188-66-6.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 268.3±23.0 °C(Predicted)
• Appearance: /
• Density: 1.194±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Benzenepropanoyl chloride, 4-fluoro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanoyl chloride, 4-fluoro-(133188-66-6)
• EPA Substance Registry System: Benzenepropanoyl chloride, 4-fluoro-(133188-66-6)

Safety Data

• Hazardous Substances Data: 133188-66-6(Hazardous Substances Data)

Upstream product

• 589-06-0 4-(4-fluorophenyl)butanoic acid 
• 462-06-6 fluorobenzene 
• 366-77-8 4-(4-fluorophenyl)-4-oxopropionic acid 
• 51787-96-3 5-(4-fluorophenyl)dihydrofuran-2(3H)-one 

Downstream Products

• 1245320-17-5 1-(4-(5-amino-2-(3-(4-fluorophenyl)propyl)thiazolo[5,4-d]pyrimidin-7-yl)piperazin-1-yl)-2-(4-chlorophenoxy)ethanone 
• 1245320-12-0 2-(3-(4-fluorophenyl)propyl)-7-(piperazin-1-yl)thiazolo[5,4-d]pyrimidin-5-amine 
• 3132-92-1 7-fluoro-naphthalen-1-ol 
• 2840-44-0 7-fluoro-3,4-dihydronaphthalen-1(2H)-one 
• 439-85-0 2-[3-(4-fluoro-phenyl)-propyl]-3-hydroxy-[1,4]naphthoquinone 
• 90432-58-9 (+/-)-5-(4-fluorophenyl)-2-pyrrolidone 

Relevant articles and documents

Enantioselective Remote C(sp3)-H Cyanation via Dual Photoredox and Copper Catalysis

The remote C(sp3)-H cyanation of carboxamides has been described by merging photoredox and copper catalysis in a site-selective and enantiocontrolled manner. The protocol is the integration of photoinduced and nitrogen-centered radical-mediated intermolecular hydrogen atom transfer with chiral copper-complex-catalyzed radical cyanation. This strategy gives enantio-enriched cyanated amides in high yields.

Synthetic Utility of N-Benzoyloxyamides as an Alternative Precursor of Acylnitrenoids for γ-Lactam Formation

Described herein is the development of a new entry of acylnitrenoid precursors for γ-lactam synthesis via an intramolecular C-H amidation reaction. Upon Ir catalysis, N-benzoyloxyamides serve as efficient substrates to afford 5-membered amides. Mechanistic studies revealed that the generation of a putative Ir-carbonylnitrenoid via N-O bond cleavage is facilitated by the chelation of countercations. This protocol offers a convenient and step-economic route to γ-lactams starting from the corresponding carboxylic acids.

Bicyclic amide derivatives and their use as muscle relaxants

Novel compounds of formula (1) together with their salts and solvates have a number of uses in medicine, in particular as central muscle relaxants.