133324-34-2

Basic information

• Product Name: N²-(2-methylpropanoyl)-2',3',5'-tris-O-(2-methylpropanoyl)-O⁶-(2''',4''',6'''-triisopropylphenylsulfonyl)guanosine
• Synonyms: N²-(2-methylpropanoyl)-2',3',5'-tris-O-(2-methylpropanoyl)-O⁶-(2''',4''',6'''-triisopropylphenylsulfonyl)guanosine
• CAS NO: 133324-34-2
• Molecular Weight: 830.012
• Mol File: 133324-34-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N²-(2-methylpropanoyl)-2',3',5'-tris-O-(2-methylpropanoyl)-O⁶-(2''',4''',6'''-triisopropylphenylsulfonyl)guanosine(CAS DataBase Reference)
• NIST Chemistry Reference: N²-(2-methylpropanoyl)-2',3',5'-tris-O-(2-methylpropanoyl)-O⁶-(2''',4''',6'''-triisopropylphenylsulfonyl)guanosine(133324-34-2)
• EPA Substance Registry System: N²-(2-methylpropanoyl)-2',3',5'-tris-O-(2-methylpropanoyl)-O⁶-(2''',4''',6'''-triisopropylphenylsulfonyl)guanosine(133324-34-2)

Safety Data

• Hazardous Substances Data: 133324-34-2(Hazardous Substances Data)

Upstream product

• 118-00-3 G 
• 70337-80-3 N²-(2-methylpropanoyl)-2',3',5'-tris-O-(2-methylpropanoyl)guanosine 
• 6553-96-4 2,4,6-triisopropylphenylsulfonyl chloride 
• 97-72-3 2-Methylpropionic anhydride 

Downstream Products

• 3001-34-1 6-18O>guanosine 
• 118-00-3 G 

Relevant articles and documents

32. Biosynthetic production of [N2,1,3,7,9-15N]guanosine and [1,3,7,9-15N]inosine and conversion into [N6,1,3,7,9-15N]adenosine for structure elucidation of RNA by heteronuclear NMR

A procedure was developed for the biosynthetic preparation of 15N-labelled guanosine and inosine through the action of a mutant Bacillus subtilis strain. Crude [N2,1,3,7,9-15N]guanosine and [1,3,7,9-15N]inosine were isolated from the culture filtrate by precipitation and anion-exchange chromatography. No cell lysis and no enzymatic degradation was necessary. The per-isobutyrylated derivatives 1 and 2 were isolated from a complex mixture, purified by virtue of their different lipophilicity, and separated in three steps involving normal- and reversed-phase silica-gel chromatography. One litre of complex nutrient medium yielded 8.44 mmol of guanosine derivative and 2.84 mmol of inosine derivative with high average 15N enrichment (83.5 and 91.9 atom-%, resp.). [N6,1,3,7,9-15N]Adenosine (4) was obtained from 2',3',5'-tri-O-isobutyryl[1,3,7,9-15N]inosine (1) through the ammonolysis of its 1,2,4-triazolyl derivative with aqueous 15NH3.