133407-86-0 Usage
Description
MG-115, also known as (S)-MG115, is a potent and reversible proteasome inhibitor that specifically targets the chymotryptic site on the 20S particle with a Ki value of 21 nM. It is known for its ability to reduce the degradation of ubiquitin-conjugated proteins in extracts and block the degradation of both longand short-lived proteins in intact cells. MG-115 also inhibits the proteolytic generation of various proteins, including NF-κB, antigens, and p53. Its action as a proteasome inhibitor can lead to the induction of a heat shock response and apoptosis, particularly in cancer cells.
Uses
Used in Pharmaceutical and Biomedical Research:
MG-115 is used as a research compound for studying the role of the proteasome in cellular processes and its inhibition in the context of various diseases, particularly cancer.
Used in Cancer Therapy:
MG-115 is used as a potential therapeutic agent for the treatment of cancer. Its ability to induce apoptosis and a heat shock response in cancer cells makes it a promising candidate for cancer treatment.
Used in Drug Development:
MG-115 serves as a lead compound in the development of new drugs targeting the proteasome, which can be used in the treatment of various diseases, including cancer and other proteinopathies.
Used in Biochemistry and Molecular Biology:
MG-115 is used as a tool in biochemical and molecular biology research to investigate the mechanisms of protein degradation and the role of the proteasome in cellular regulation.
Biochem/physiol Actions
Product does not compete with ATP.
references
1. involvement of heat shock protein 90 in the degradation of mutant insulin receptors by the proteasome. imamura, t., haruta, t., takata, y., usui, i., iwata, m., ishihara, h., ishiki, m., ishibashi, o., ueno, e., sasaoka, t., kobayashi, m. j. biol. chem. (1998)
Check Digit Verification of cas no
The CAS Registry Mumber 133407-86-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,3,4,0 and 7 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 133407-86:
(8*1)+(7*3)+(6*3)+(5*4)+(4*0)+(3*7)+(2*8)+(1*6)=110
110 % 10 = 0
So 133407-86-0 is a valid CAS Registry Number.
133407-86-0Relevant articles and documents
Proteasome regulation of NF-KB activity
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Page column 43, (2008/06/13)
Disclosed herein is a method for regulating the activity of NF-κB in an animal comprising contacting cells of the animal with certain proteasome inhibitors.
