1334287-93-2Relevant articles and documents
Catalytic Asymmetric Reduction of α-Trifluoromethylated Imines with Catecholborane by BINOL-Derived Boro-phosphates
He, Hualing,Tang, Xiaoxue,Cao, Yang,Antilla, Jon C.
, p. 4336 - 4345 (2021/03/01)
A catalytic enantioselective reduction of α-trifluoromethylated imines by a BINOL-derived boro-phosphate employing catecholborane as hydride source has been developed. This method provides an efficient route to prepare synthetically useful chiral α-triflu
Stereoselective metal-free catalytic synthesis of chiral trifluoromethyl aryl and alkyl amines
Genoni, Andrea,Benaglia, Maurizio,Massolo, Elisabetta,Rossi, Sergio
, p. 8365 - 8367 (2013/09/23)
The enantioselective organocatalytic reduction of trifluoromethyl aryl and alkyl ketoimines afforded the corresponding fluorinated amines with high chemical and stereochemical efficiency. The Lewis base catalyzed reaction with trichlorosilane led to chiral products with a trifluoromethyl group directly linked to the newly generated stereocenter typically in >90% yield and up to 98% e.e.
Chiral phosphoric acid catalyzed transfer hydrogenation: Facile synthetic access to highly optically active trifluoromethylated amines
Henseler, Alexander,Kato, Masanori,Mori, Keiji,Akiyama, Takahiko
supporting information; experimental part, p. 8180 - 8183 (2011/10/09)
Amines to an end: Highly optically active α-CF3- functionalized amines can be obtained using metal-free reaction conditions. The method involves the transfer hydrogenation of CF3-substituted ketimines catalyzed by 1 and reductive ami
