133444-98-1Relevant articles and documents
Oxadiazole and its salts, their use in treating dementia
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, (2008/06/13)
The compound (3R, 4R)-3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-1-azabicyclo[2.2.1]heptane and its salts behave as a functionally selective muscarinic agonist and are useful in the treatment of neurological and mental disorders, preferably in a pharmaceutical formulation comprising the active compound in association with a pharmaceutically acceptable carrier. The compound can be prepared by methods analogous to those known in the art via suitable chiral intermediates and cyclopropyl carboxamide oxime.
Substituted oxadiazoles and thiadiazoles for use in the treatment of glaucoma
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, (2008/06/13)
The use of compounds for formula (I): STR1 or a salt or prodrug thereof; wherein one of X, Y, or Z is an oxygen or sulphur atom and the other two are nitrogen atoms, and the dotted circle represents two double bonds thus forming a 1,3,4-oxadiazole, 1,2,4-oxadiazole, 1,3,4-thiadiazole or 1,2,4-thiadiazole nucleus; R1 represents a non-aromatic azacyclic or azabicyclic ring system selected from STR2 wherein the broken line represents an optional chemical bond; the substituents R3 and R4 may be present at any position, including the point of attachment to the oxa- or thia-diazole ring, and independently represent hydrogen, C1-4 alkyl, halo, C1-4 alkoxy, hydroxy or carboxy, or R3 and R4 together represent carbonyl; the group R5 represents hydrogen or C1-4 alkyl; and R2 represents hydrogen, C1-8 hydrogen, C1-8 alkyl optionally substituted by hydroxy or fluoro, C2-8 alkenyl, OR7, SR7, NR7 R8, CN, CO2 R7, CONR7 R8 OR NHCONHR9 where R9 is C1-4 alkyl; wherein R7 and R8 independently represent hydrogen or saturated or unsaturated C1-4 alkyl provided that, when R7 and R8 in NR7 R8 are both hydrogen, at least one of R3 and R4 is C1-4 alkyl, in the treatment of glaucoma, novel compounds having such use, formulations containing them and their synthesis.
