133444-99-2Relevant articles and documents
Synthesis, Physicochemical and Conformational Properties of (3R,4R)-3-(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)-1-azabicycloheptane, a Novel M1 Selective Muscarinic Partial Agonist
Baker, Raymond,Showell, Graham A.,Street, Leslie J.,Saunders, John,Hoogsteen, Karst,et al.
, p. 817 - 819 (1992)
The cyclopropyloxadiazole derivative described in the title has been shown to be a functionally selective M1 partial agonist with antagonist properties in M2 and M3 muscarinic receptor assays; conformational studies indicate free rotation around the oxadiazole-azanorbornane bond, whilst X-ray studies reveal that the cyclopropyl group is in conjugation with the oxadiazole C=N bond.