1334752-47-4

Basic information

• Product Name: 2-methoxy-5-(4,5,6-trimethoxy-indol-1-yl)-phenylamine
• Synonyms: 2-methoxy-5-(4,5,6-trimethoxy-indol-1-yl)-phenylamine
• CAS NO: 1334752-47-4
• Molecular Weight: 328.368
• Mol File: 1334752-47-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-methoxy-5-(4,5,6-trimethoxy-indol-1-yl)-phenylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methoxy-5-(4,5,6-trimethoxy-indol-1-yl)-phenylamine(1334752-47-4)
• EPA Substance Registry System: 2-methoxy-5-(4,5,6-trimethoxy-indol-1-yl)-phenylamine(1334752-47-4)

Safety Data

• Hazardous Substances Data: 1334752-47-4(Hazardous Substances Data)

Upstream product

• 30448-04-5 4,5,6-trimethoxy-1H-indole 
• 52692-09-8 4-iodo-2-nitroanisole 

Relevant articles and documents

Synthesis and biological evaluation of 1-(4′-Indolyl and 6′-Quinolinyl) indoles as a new class of potent anticancer agents

A novel series of the biheterocycles-based compounds with core structure distinguished from combretastatin A-4 (1) and colchicine (5) have been synthesized and evaluated as potent anti-mitotic agents. Compound 1-(4′-Indolyl and 6′-quinolinyl)-4,5,6-trimethoxyindoles 13 and 19 showed substantial anti-proliferative activity against various human cancer cell lines, regardless to the tissue origin and the expression of multiple-drug resistance MDR1, with a mean IC50 value of 38 and 24 nM respectively. Compound 13 (IC50 = 1.7 μM) also exhibited similar anti-tubulin activities to 1 (IC50 = 1.8 μM) and displayed strong binding property to the colchicine binding site on the microtubules. Computational modeling analysis revealed that the binding mechanism of compound 13 is similar to that of CA4.