1335242-34-6Relevant articles and documents
Synthesis and biological evaluation of novel (E) stilbene-based antitumor agents
Csuk, Rene,Albert, Sabrina,Siewert, Bianka,Schwarz, Stefan
experimental part, p. 669 - 678 (2012/09/07)
Several new (E) stilbenes were synthesized by a combination of a Wittig olefination followed by Mizoroki-Heck coupling reactions. These compounds were screened for antitumor activity in a panel of 8 human cancer cell lines by a colorimetric SRB assay. Several of these compounds exhibit strong cytotoxicity. The most active compound of this series showed an average IC50 value of 0.03 μmol; it acts by apoptosis as shown by a dye-exclusion test, an extra acridine orange/ethidium bromide staining and DNA-laddering experiments.