133787-61-8 Usage
Description
14-O-[(1-AMino-2-Methylpropan-2-yl)thioacetyl]Mutilin is a chemical compound derived from the mutilin class of antibiotics. It is characterized by its unique chemical structure, which includes a thioacetyl group attached to the 14-O position and a 1-amino-2-methylpropan-2-yl group. 14-O-[(1-AMino-2-Methylpropan-2-yl)thioacetyl]Mutilin is known for its potential applications in the development of novel antibacterial agents, particularly in the context of pleuromutillin derivatives.
Uses
Used in Pharmaceutical Industry:
14-O-[(1-AMino-2-Methylpropan-2-yl)thioacetyl]Mutilin is used as an intermediate in the synthesis of novel pleuromutillin derivatives for the development of new antibacterial agents. The compound plays a crucial role in the creation of these derivatives, which are designed to combat bacterial infections, especially those caused by drug-resistant strains.
Application Reason:
The development of novel pleuromutillin derivatives is essential due to the increasing prevalence of antibiotic-resistant bacteria. These derivatives aim to provide more effective treatment options for various bacterial infections, addressing the urgent need for new antibiotics in the face of growing resistance.
Check Digit Verification of cas no
The CAS Registry Mumber 133787-61-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,3,7,8 and 7 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 133787-61:
(8*1)+(7*3)+(6*3)+(5*7)+(4*8)+(3*7)+(2*6)+(1*1)=148
148 % 10 = 8
So 133787-61-8 is a valid CAS Registry Number.
133787-61-8Relevant articles and documents
An antimycobacterial pleuromutilin analogue effective against dormant bacilli
Lemieux, Maddie R.,Siricilla, Shajila,Mitachi, Katsuhiko,Eslamimehr, Shakiba,Wang, Yuehong,Yang, Dong,Pressly, Jeffrey D.,Kong, Ying,Park, Frank,Franzblau, Scott G.,Kurosu, Michio
, p. 4787 - 4796 (2018)
Pleuromutilin is a promising pharmacophore to design new antibacterial agents for Gram-positive bacteria. However, there are limited studies on the development of pleuromutilin analogues that inhibit growth of Mycobacterium tuberculosis (Mtb). In screenin
PLEUROMUTILIN DERIVATIVES AND USES THEREOF
-
, (2018/09/18)
Provided herein are pleuromutilin derivatives and analogs that are useful antimicrobial agents against Acinetobacter baumannii and Mycobacterium.
Synthesis and antibacterial evaluation of novel pleuromutilin derivatives
Shang, Ruofeng,Liu, Yu,Xin, Zhijun,Guo, Wenzhu,Guo, Zhiting,Hao, Baocheng,Jianping, Liang
, p. 231 - 238 (2013/07/27)
A series of novel pleuromutilin derivatives possessing thioether moiety has been synthesized via acylation reaction under mild conditions. Their in vitro antibacterial activity against methicillin-resistant Staphylococcus aureus, methicillin-resistant Staphylococcus epidermidis, Escherichia coli, and Streptococcus agalactiae were tested by agar dilution method and Oxford cup assay. Among the 17 compounds screened, 14-O-[(4-methoxybenzamide-2- methylpropane-2-yl) thioacetate] mutilin 4i, 14-O-[(2-aminobenzamide-2- methylpropane-2-yl) thioacetate] mutilin 5a and 14-O-[(4-aminobenzamide-2- methylpropane-2-yl) thioacetate] mutilin 5c were resulted as most active antibacterial agents.
