13380-32-0

Basic information

• Product Name: 1H-Isoindol-1-one, 2,3-dihydro-2-(phenylmethyl)-
• CAS NO: 13380-32-0
• Molecular Formula: C15H13NO
• Molecular Weight: 223.274
• Mol File: 13380-32-0.mol
• Article Data: 42

Chemical Properties

• CAS DataBase Reference: 1H-Isoindol-1-one, 2,3-dihydro-2-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Isoindol-1-one, 2,3-dihydro-2-(phenylmethyl)-(13380-32-0)
• EPA Substance Registry System: 1H-Isoindol-1-one, 2,3-dihydro-2-(phenylmethyl)-(13380-32-0)

Safety Data

• Hazardous Substances Data: 13380-32-0(Hazardous Substances Data)

Usage

Heterocyclic organic compound

1H-Isoindol-1-one, 2,3-dihydro-2-(phenylmethyl)is a compound that contains a ring structure containing both carbon and a heteroatom (such as nitrogen or oxygen) atoms.

Building block for biologically active compounds

1H-Isoindol-1-one, 2,3-dihydro-2-(phenylmethyl)is used as a starting material in the synthesis of many biologically active compounds and pharmaceutical drugs.

Wide range of pharmacological activities

This compound has been found to exhibit a variety of pharmacological activities, including the ability to modulate neurotransmitter systems in the brain.

Potential applications in the treatment of neurological and psychiatric disorders

Due to its ability to modulate neurotransmitter systems, 1H-Isoindol-1-one, 2,3-dihydro-2-(phenylmethyl)has potential applications in the treatment of various neurological and psychiatric disorders.

Used in the synthesis of therapeutic agents and natural products

This compound is also used as an intermediate in the synthesis of various therapeutic agents and natural products.

Upstream product

• 1365890-61-4 C₁₅H₁₅NO₃ 
• 100-46-9 benzylamine 
• 119-67-5 o-carboxybenzaldehyde 
• 201230-82-2 carbon monoxide 
• 56008-40-3 N-benzyl-1-(2-iodophenyl)methanamine 
• 103-49-1 dibenzylamine 
• 35180-14-4 N-benzylisoindoline 
• 91-13-4 α,α'-dibromo-o-xylene 
• 2142-01-0 N-benzylphthalimide 
• 643-79-8 o-phthalic dicarboxaldehyde 
• 101584-40-1 ethyl dibenzylcarbamate 
• 4122-56-9 methyl o-formylbenzoate 
• 78-79-5 isoprene 
• 1616596-98-5 potassium (1-oxoisoindolin-2-yl)methyltrifluoroborate 

Downstream Products

• 1311147-15-5 2-benzyl-3-(4-methoxyphenyl)isoindolin-1-one 
• 1422962-09-1 2-benzyl-3-(4-chlorophenyl)isoindolin-1-one 
• 68972-63-4 2-benzyl-3-(4-chlorophenyl)-3-hydroxy-2,3-dihydroisoindolin-1-one 
• 82359-81-7 2,3-dihydro-3-methylene-2-benzyl-1H-isoindolone 
• 113859-53-3 7-benzyl-2,3:5,6-dibenzo-7-azabicyclo<2.2.1>hepta-2,5-diene 
• 123542-36-9 10-benzyl-2-phenyl-3a,4,9,9a-tetrahydro-1H-4,9-epiminobenzo[f]isoindole-1,3(2H)-dione 
• 35180-14-4 N-benzylisoindoline 
• 25473-60-3 2-benzyl-2H-isoindole 
• 1600522-56-2 diethyl [3-(2-benzyl-3-oxo-2,3-dihydro-1H-isoindol-1-yl)propyl]phosphonate 
• 1600522-46-0 diethyl [2-(2-benzyl-3-oxo-2,3-dihydro-1H-isoindol-1-yl)ethyl]phosphonate 
• 2142-01-0 N-benzylphthalimide 

Relevant articles and documents

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Synthesis of α,β-unsaturated lactams by palladium-catalysed intramolecular carbonylative coupling

Amino vinyl triflates have been shown to undergo an intramolecular, carbonylative coupling in the presence of a palladium catalyst to afford α,β-unsaturated lactams.

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Chemoselective Electrosynthesis Using Rapid Alternating Polarity

Challenges in the selective manipulation of functional groups (chemoselectivity) in organic synthesis have historically been overcome either by using reagents/catalysts that tunably interact with a substrate or through modification to shield undesired sites of reactivity (protecting groups). Although electrochemistry offers precise redox control to achieve unique chemoselectivity, this approach often becomes challenging in the presence of multiple redox-active functionalities. Historically, electrosynthesis has been performed almost solely by using direct current (DC). In contrast, applying alternating current (AC) has been known to change reaction outcomes considerably on an analytical scale but has rarely been strategically exploited for use in complex preparative organic synthesis. Here we show how a square waveform employed to deliver electric current - rapid alternating polarity (rAP) - enables control over reaction outcomes in the chemoselective reduction of carbonyl compounds, one of the most widely used reaction manifolds. The reactivity observed cannot be recapitulated using DC electrolysis or chemical reagents. The synthetic value brought by this new method for controlling chemoselectivity is vividly demonstrated in the context of classical reactivity problems such as chiral auxiliary removal and cutting-edge medicinal chemistry topics such as the synthesis of PROTACs.

One-pot method to construct isoindolinones and its application to the synthesis of DWP205109 and intermediate of Lenalidomide

Herein a practical and efficient system for concise synthesis of isoindolinones is described by using substituted methyl 2-(halomethyl)benzoates and substituted amines. Structurally various methyl 2-(halomethyl)benzoates and amines were transformed into isoindolinones 80–99% yield and purity in catalyst-free and solvent-free conditions. The method has a wide substrate scope. The synthetic utility of the one-pot reaction was demonstrated by the concise syntheses of Lenalidomide intermediate and DWP205190.