133855-98-8Relevant articles and documents
Evaluating the enantioselective distribution, degradation and excretion of epoxiconazole in mice following a single oral gavage
Wang, Dezhen,Qiu, Jing,Zhu, Wentao,Zhang, Ping,Deng, Nian,Wang, Xinru,Wang, Yao,Zhou, Zhiqiang
, p. 1009 - 1015 (2015)
1. The enantiomeric enrichment or degradation of epoxiconazole has been reported in grape, soil, tubifex and mealworm beetle. But, little is known about its enantioselective behaviors in mammals.2. To further understand differences in the distribution, degradation and excretion of epoxiconazole enantiomers in vivo, male CD-1 mice were selected as the test model to investigate the enantioselective behaviors after a single oral gavage. Mice were sacrificed after 1 h, 3 h, 7 h, 12 h, 24 h, 48 h, 72 h treatment, blood, tissues and excretions were collected for epoxiconazole analysis by LC-MS/MS.3. On the Lux-Cellulose-1 chiral column, an enrichment of the second eluting (+)-epoxiconazole was generally observed, and feces and urine showed similar EF with major tissues.4. To elucidate the potential role of intestinal bacterial flora in stereospecific degradation of epoxiconazole, mice fecal flora were cultured in vitro and incubated with epoxiconazole for 48 h. Results showed that (-)-epoxiconazole was preferentially degraded by intestinal bacterial.5. These results may provide useful information for risk assessment of epoxiconazole on non-target animals.
Method for reducing 1,3,4-triazole substituent in 1,2,4-triazole alkylation reaction process
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Paragraph 0031-0034, (2019/12/25)
The invention relates to a method for reducing a 1,3,4-triazole substituent in 1,2,4-triazole alkylation reaction process. The method comprises the steps that 1, 2, 4-triazole and an alkylation reagent are subjected to an alkylation reaction in the presence of an alkali and a catalyst, after the reaction is finished, 1, 2, 4-triazole substituent is obtained through aftertreatment, and the catalystis one or a combination of more of polyether, cyclic crown ether, quaternary ammonium salt, quaternary phosphorus salt, quaternary ammonium base and tertiary amine. The method is simple to operate; the method is wide in application range, the content of the 1, 3, 4-triazole substituent in the alkylation reaction process can be reduced, the yield of the 1, 2, 4-triazole substituent is increased, the reaction time is shortened, the reaction temperature is reduced, solvent use is reduced or avoided, the resource utilization rate is increased, three wastes are reduced, the production cost is reduced, and the method meets the requirements of a green and environment-friendly process.
Epoxiconazole intermediate, preparation method thereof, and preparation method of epoxiconazole
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Paragraph 0071; 0072-0076; 0081, (2019/02/13)
The invention relates to an epoxiconazole intermediate, a preparation method thereof, and a preparation method of epoxiconazole. The epoxiconazole intermediate is a compound with a structural formulaIII shown in the description, and X in the formula III is Br or Cr. The preparation methods have the advantages of cheap and easily available raw materials, simple steps, high safety, few pollution ofthree wastes, mild reaction conditions, green, clean and environmentally-friendly reagents and reaction processes, suitableness for industrial production, and realization of high yield and high content of the final products.
