134079-95-1Relevant articles and documents
A Novel One-Step Synthesis of 4H-Furopyrans and a Transformation into a Difuropyridine
Martin, Nazario,Segura, Jose L.,Seoane, Carlos,Soto, Jose L.,Morales, Margarita,Suarez, Margarita
, p. 827 - 830 (2007/10/02)
A simple one-step synthesis of 2-amino-4-aryl-5-oxo-4H-furopyran-3-carbonitriles 7 is described.It involves reaction of 2,4(3H,5H)-furandione (β-tetronic acid) (5) with arylmethylenemalononitriles 4 in basic medium.Some substituent effects are noted and the assignments of 13C-NMR spectra are discussed.Ring transformation of the furopyran 7a leads to the difuropyridine 9.Key Words: Furopyrans / Difuropyridine / β-Tetronic acid / Malononitriles, arylmethylene-