134107-69-0

Basic information

• Product Name: BOC-D-4-THIAZOLYLALANINE
• Synonyms: N-Boc-3-(4-thiazolyl)-D-alanine, 98%;N-ALPHA-T-BUTOXYCARBONYL-3-(4-THIAZOLYL)-D-ALANINE;(R)-N-ALPHA-T-BUTOXYCARBONYL-3-(4-THIAZOLYL)-ALANINE;(R)-N-BOC-4-THIAZOYLALANINE;RARECHEM BK PT 0201;BOC-3-(4-THIAZOLYL)-D-ALANINE;BOC-D-ALA(4-THIAZOYL)-OH;BOC-D-ALA(4-THZ)-OH
• CAS NO: 134107-69-0
• Molecular Formula: C₁₁H₁₆N₂O₄S
• Molecular Weight: 272.32
• Product Categories: Phenylalanine analogs and other aromatic alpha amino acids;a-amino
• Mol File: 134107-69-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 456.788 °C at 760 mmHg
• Flash Point: 230.057 °C
• Appearance: /
• Density: 1.288
• Storage Temp.: Store at -15°C
• PKA: 3.53±0.10(Predicted)
• CAS DataBase Reference: BOC-D-4-THIAZOLYLALANINE(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-D-4-THIAZOLYLALANINE(134107-69-0)
• EPA Substance Registry System: BOC-D-4-THIAZOLYLALANINE(134107-69-0)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 134107-69-0(Hazardous Substances Data)

Usage

General Description

Boc-D-4-Thiazolylalanine is a synthetic amino acid derivative with a Boc (tert-butyloxycarbonyl) protecting group attached to the N-terminus. It is commonly used in peptide synthesis and pharmaceutical research. The 4-thiazolylalanine moiety gives the compound unique properties and can be used to modify the structure and properties of peptides for various applications. Boc-D-4-Thiazolylalanine is often utilized in the development of peptide-based drugs and therapeutic agents due to its ability to enhance the biological activity and stability of peptides. Its specific chemical structure and properties make it a valuable tool in the field of medicinal chemistry and drug discovery.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 134038-92-9 1-<(R)-3-benzyloxycarbonyl-5-oxo-4-oxazolidinone>-3-chloro-2-propanone 
• 134038-93-0 4-<(R)-3-benzyloxycarbonyl-5-oxo-4-oxazolidinone>methylthiazole 

Downstream Products

• 134362-80-4 [1-(R)-(1-(S)-cyclohexylmethyl-3-cyclopropyl-2-(R),3(S)-dihydroxy-propylcarbamoyl)-thiazol-4-yl-ethyl]-carbamic acid tert-butyl ester 
• 131896-42-9 (2R)-2-amino-3-(thiazol-4-yl)propanoic acid 
• 1416467-86-1 4-[5-(cyclopropylmethoxy)-1,3-benzodioxol-4-yl]-N-[(2R)-1-{4-[(4aS,8aR)-4-(3,4-dimethoxyphenyl)-1-oxo-4a,5,6,7,8,8a-hexahydrophthalazin-2(1H)-yl]piperidin-1-yl}-1-oxo-3-(1,3-thiazol-4-yl)propan-2-yl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide 
• 1416469-39-0 tert-butyl [(2R)-1-{4-[(4aS,8aR)-4-(3,4-dimethoxyphenyl)-1-oxo-4a,5,6,7,8,8a-hexahydrophthalazin-2(1H)-yl]piperidin-1-yl}-1-oxo-3-(1,3-thiazol-4-yl)propan-2-yl]carbamate 
• 1416469-40-3 (4aS,8aR)-2-{1-[(2R)-2-amino-3-(1,3-thiazol-4-yl)propanoyl]piperidin-4-yl}-4-(3,4-dimethoxyphenyl)-4a,5,6,7,8,8a-hexahydrophthalazin-1(2H)-one hydrochloride 

Relevant articles and documents

ENCAPSULATED RENIN INHIBITOR COMPOSITION

A pharmaceutical composition comprising a solution of a tenin inhibitor of the formula: STR1 wherein R 1 is 4-piperazinyl, 1-methyl-4-piperazinyl, 1-methyl-1-oxo-4-piperazinyl, 2-oxo-4-piperazinyl, 4-morpholinyl, 4-thiomorpholinyl or 1-methyl-4-homopiperazinyl; R 2 is benzyl, p-methoxybenzyl, 2-phenylethyl, 1-naphthylmethyl or 2-naphthylmethyl;R 3 is 4-thiazolyl, 2-amino-4-thiazolyl, 2-thiazolyl, 5-thiazolyl, 1-pyrazolyl, 3-pyrazolyl, 1-imidazolyl, n-propyl, isopropyl, CH 3 S--or CH 3 SCH 2--;R 4 is loweralkyl or cyclopropyl;R 5 is hydrogen or loweralkyl; andX is CH 2 or NH; or a pharmaceutically acceptable salt, ester or prodrug thereof in a pharmaceutically acceptable solvent, said solution being encapsulated in a soft elastic gelatin capsule.

Synthesis of N-(tert-Butoxycarbonyl)-3-(4-thiazolyl)-L-alanine

Efficient syntheses of N-(tert-butoxycarbonyl)-3-(4-thiazolyl)-L-alanine (11) are described.