134221-52-6 Usage
Description
5-Pyrimidinecarboxaldehyde, 4-chloro-2,6-dimethoxyis an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceutical compounds. It is characterized by its unique molecular structure, which includes a pyrimidine ring with a formyl group at the 5-position, a chlorine atom at the 4-position, and two methoxy groups at the 2 and 6 positions. 5-Pyrimidinecarboxaldehyde, 4-chloro-2,6-dimethoxyplays a significant role in the development of drugs targeting specific enzymes and metabolic pathways.
Uses
Used in Pharmaceutical Industry:
5-Pyrimidinecarboxaldehyde, 4-chloro-2,6-dimethoxyis used as a key intermediate in the synthesis of 4,6-Dihydroxypyrazolo[3,4-d]pyrimidine (D454550) for its role in the development of xanthine oxidase inhibitors. This application is significant because xanthine oxidase inhibitors, such as Allopurinol (A547300), are widely used in the treatment of gout and hyperuricemia by reducing the levels of uric acid in the body.
Furthermore, 4,6-Dihydroxypyrazolo[3,4-d]pyrimidine is a major metabolite of Allopurinol, which highlights the importance of 5-Pyrimidinecarboxaldehyde, 4-chloro-2,6-dimethoxyin the pharmaceutical industry. The synthesis of such metabolites and their subsequent incorporation into drug development can lead to the creation of more effective and targeted treatments for various medical conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 134221-52-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,4,2,2 and 1 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 134221-52:
(8*1)+(7*3)+(6*4)+(5*2)+(4*2)+(3*1)+(2*5)+(1*2)=86
86 % 10 = 6
So 134221-52-6 is a valid CAS Registry Number.
134221-52-6Relevant articles and documents
Discovery of 5-substituted-6-chlorouracils as efficient inhibitors of human thymidine phosphorylase
Nencka, Radim,Votruba, Ivan,H?ebabecky, Hubert,Jansa, Petr,Tlou?t'ová, Eva,Horská, Květa,Masojídková, Milena,Holy, Antonín
, p. 6016 - 6023 (2008/09/17)
Thymidine phosphorylase plays an important role in angiogenesis, which is an attractive target for therapy of cancer and other diseases. In our continuous effort to develop novel inhibitors of thymidine phosphorylase, we have discovered that 6-halouracils substituted at position C5 by certain hydrophobic groups exhibit significant inhibitory activity against this enzyme. The most potent compounds bear a five- or six-membered cyclic substituent containing a π-electron system at C5 and a chlorine atom attached at C6. 6-Chloro-5-cyclopent-1-en-1-yluracil 7a is the most efficient derivative in this study, with Ki = 0.20 ± 0.03 μM (Ki/ dThdKm = 0.0017) for thymidine phosphorylase expressed in V79 cells and Ki = 0.29 ± 0.04 μM (Ki/ dThdKm = 0.0024) for the enzyme purified from placenta.
Metallation of diazines. III. New synthesis of analogues of trimethoprim and of bacimethrin
Ple,Turck,Fiquet,Queguiner
, p. 283 - 288 (2007/10/02)
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