134295-41-3

Basic information

• Product Name: 2-(4-Fluoro-phenyl)-2-{4-[(4-fluoro-phenyl)-hydroxy-methyl]-piperidin-1-yl}-ethanol
• CAS NO: 134295-41-3
• Molecular Weight: 347.405
• Mol File: 134295-41-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(4-Fluoro-phenyl)-2-{4-[(4-fluoro-phenyl)-hydroxy-methyl]-piperidin-1-yl}-ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Fluoro-phenyl)-2-{4-[(4-fluoro-phenyl)-hydroxy-methyl]-piperidin-1-yl}-ethanol(134295-41-3)
• EPA Substance Registry System: 2-(4-Fluoro-phenyl)-2-{4-[(4-fluoro-phenyl)-hydroxy-methyl]-piperidin-1-yl}-ethanol(134295-41-3)

Safety Data

• Hazardous Substances Data: 134295-41-3(Hazardous Substances Data)

Upstream product

• 18511-62-1 R-(-)-2-(4-fluorophenyl)oxirane 
• 134295-36-6 R-(+)-4-(4-fluorophenyl)hydroxymethyl-piperidine 
• 134295-35-5 S-(-)-4-(4-fluorophenyl)hydroxymethyl-piperidine 
• 18511-62-1 (2S)-2-(4-fluorophenyl)oxirane 
• 456-04-2 2-Chloro-4'-fluoroacetophenone 
• 134356-72-2 R-(+)-1-benzyloxycarbonyl-4-(4-fluorophenyl)hydroxymethyl-piperidine 
• 134356-71-1 S-(-)-1-benzyloxycarbonyl-4-(4-fluorophenyl)hydroxymethyl-piperidine 
• 134295-32-2 1-benzyloxycarbonyl-4-(4-fluorophenyl)hydroxymethyl-piperidine 
• 126534-43-8 [R]-1-chloro-2-(4-fluorophenyl)-2-ethanol 
• 61592-48-1 2-Chloro-1-(4-fluorophenyl)ethanol 
• 134295-33-3 R-(+)-1-benzyloxycarbonyl-4-(4-fluorophenyl)acetoxymethyl-piperidine 
• 131417-40-8 1-benzyloxycarbonyl-4-(4-fluorobenzoyl)-piperidine 
• 134295-34-4 S-(+)-2-chloro-1-(4-fluorophenyl)ethanol acetate 
• 56346-57-7 (4-fluorophenyl)-piperidin-4-ylmethanone 

Relevant articles and documents

Multigram lipase-catalyzed enantioselective acylation in the synthesis of the four stereoisomers of a new biologically active α-aryl-4-piperidinemethanol derivative

The four stereoisomers of the novel non-narcotic analgesic 1-[2-(4-fluorophenyl)-2-hydroxyethyl]-4-[(4-fluorophenyl)hydroxymethyl ]-piperidine 1 were synthesized in a convergent manner from chiral precursors 2 and 3. Optical resolution via enantioselective acylation in organic media, catalyzed by a lipase from Pseudomonas sp., was utilized in the preparation of 2 and 3 on a multigram scale with high enantiomeric purity (>97% ee).