134373-08-3

Basic information

• Product Name: tert-butyl 4-<4-(2,4,6-triaminopyrimidin-5-yl)-5,5-dimethoxypentyl>benzoate
• Synonyms: tert-butyl 4-<4-(2,4,6-triaminopyrimidin-5-yl)-5,5-dimethoxypentyl>benzoate
• CAS NO: 134373-08-3
• Molecular Weight: 431.535
• Mol File: 134373-08-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-butyl 4-<4-(2,4,6-triaminopyrimidin-5-yl)-5,5-dimethoxypentyl>benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-<4-(2,4,6-triaminopyrimidin-5-yl)-5,5-dimethoxypentyl>benzoate(134373-08-3)
• EPA Substance Registry System: tert-butyl 4-<4-(2,4,6-triaminopyrimidin-5-yl)-5,5-dimethoxypentyl>benzoate(134373-08-3)

Safety Data

• Hazardous Substances Data: 134373-08-3(Hazardous Substances Data)

Upstream product

• 134373-02-7 tert-butyl 4-(5-methoxy-4-pentenyl)benzoate 
• 146850-31-9 tert-butyl 4-(4-oxobutyl)benzoate 
• 146850-30-8 tert-butyl 4-(4-hydroxy-1-butenyl)benzoate 
• 129623-80-9 tert-butyl 4-(4-hydroxybutyl)benzoate 
• 65874-27-3 4-(tert-butoxycarbonyl)benzaldehyde 
• 50-01-1 guanidine hydrochloride 
• 134373-03-8 tert-butyl 4-<5,5-dicyano-4-(dimethoxymethyl)pentyl>benzoate 

Downstream Products

• 125991-50-6 diethyl N-[4-[3-(2,4-diamino-7H-pyrrolo[2,3-d]-pyrimidin-5-yl)propyl]benzoyl]-L-glutamate 
• 125991-51-7 N-[4-[3-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidine-5-yl)propyl]benzoyl]-L-glutamic acid 
• 134373-15-2 4-<2-(2,4-diamino-7H-pyrrolo<2,3-d>pyrimidin-5-yl)propyl>benzoic acid 

Relevant articles and documents

A Novel Synthetic Approach to Pyrrolopyrimidine Antifolates

A novel and efficient synthetic method for the synthesis of pyrrolopyrimidine antifolates is described.The key reaction of this method is the photo-initiated free radical addition of bromomalononitrile or ethyl bromocyanoacetate to an enol ether to afford the backbone skeleton of the targeted antifolate molecule.The key intermediates 3 or 4 are smoothly converted to the pyrrolopyrimidine antifolates 1 or 2 in three steps and in high overall yield.