134470-38-5

Basic information

• Product Name: BW B70C
• Synonyms: N-[3-[3-(-FLUOROPHENOXY)PHENYL]-1-METHYL-2-PROPENYL]-N-HYDROXYUREA;N-[3-[3-4(-FLUOROPHENOXY)PHENYL]-1-METHYL-2-PROPENYL]-N-HYDROXYUREA;(e)-n-(3-(3-(4-fluorophenoxy)phenyl)-1-(r,s)-methylprop-2-enyl)-n-hydroxyure;70c;n-(3-(3-(4-fluorophenoxy)phenyl)-1-methyl-2-propenyl)-n-hydroxy-ure;BW B70C
• CAS NO: 134470-38-5
• Molecular Formula: C17H17FN2O3
• Molecular Weight: 316.33
• Mol File: 134470-38-5.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 498.9°C at 760 mmHg
• Flash Point: 255.5°C
• Appearance: white/solid
• Density: 1.295g/cm³
• Vapor Pressure: 8.96E-11mmHg at 25°C
• Refractive Index: 1.627
• Storage Temp.: 2-8°C
• Solubility: DMSO: 22 mg/mL, soluble
• CAS DataBase Reference: BW B70C(CAS DataBase Reference)
• NIST Chemistry Reference: BW B70C(134470-38-5)
• EPA Substance Registry System: BW B70C(134470-38-5)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• RTECS: YT3976666
• Hazardous Substances Data: 134470-38-5(Hazardous Substances Data)

Usage

Description

BW B70C is a hydroxamic acid derivative that functions as a selective inhibitor of arachidonate 5-lipoxygenase (5-LO). It is characterized by the replacement of both hydrogens attached to one of the nitrogens in urea with a hydroxy and a (1E)-1-[3-(4-fluorophenoxy)phenyl]but-1-en-3-yl group. BW B70C has potential applications in the treatment of asthma and other related conditions.

Uses

Used in Pharmaceutical Industry:
BW B70C is used as a 5-LO inhibitor for the treatment of asthma. By selectively inhibiting the enzyme 5-lipoxygenase, it helps to reduce the production of leukotrienes, which are inflammatory mediators that contribute to the symptoms of asthma and other respiratory conditions.
Used in Research Applications:
In addition to its potential therapeutic use, BW B70C can also be utilized as a research tool to study the role of 5-LO in various biological processes and diseases. This selective inhibition can provide valuable insights into the mechanisms underlying asthma and other inflammatory conditions, aiding in the development of novel therapeutic strategies.

Biological Activity

A potent, selective inhibitor of 5-lipoxygenase. In vivo, has a long half-life and high oral bioavailability.

references

[1]. payne an, jackson wp, salmon ja, et al. hydroxamic acids and hydroxyureas as novel, selective 5-lipoxygenase inhibitors for possible use in asthma. agents actions suppl, 1991, 34: 189-199.[2]. yeadon m, dougan fl, petrovic a, et al. effect of bw b70c, a novel inhibitor of arachidonic acid 5-lipoxygenase, on allergen-induced bronchoconstriction and late-phase lung eosinophil accumulation in sensitised guinea-pigs. agents actions, 1993, 38(1-2): 8-18.[3]. bureau mf, de castro cm, cortese c, et al. 5-lipoxygenase and endotoxin-induced microvascular albumin exchanges and leucocyte recruitment in guinea-pig lungs. eur j pharmacol, 1997, 324(1): 89-98.[4]. jatana m, giri s, ansari ma, et al. inhibition of nf-kappab activation by 5-lipoxygenase inhibitors protects brain against injury in a rat model of focal cerebral ischemia. j neuroinflammation, 2006, 3: 12.

InChI:InChI=1/C17H17FN2O3/c1-12(20(22)17(19)21)5-6-13-3-2-4-16(11-13)23-15-9-7-14(18)8-10-15/h2-12,22H,1H3,(H2,19,21)/b6-5+