134516-99-7 Usage
Description
U 90042, also known as a sedative and hypnotic compound, is a chemical substance that interacts differentially with the GABAA receptor subtypes. It is designed to modulate the activity of these receptors, which play a crucial role in regulating neuronal excitability and promoting relaxation in the central nervous system.
Uses
Used in Pharmaceutical Industry:
U 90042 is used as a sedative and hypnotic agent for its ability to interact with GABAA receptor subtypes, promoting relaxation and reducing anxiety. This makes it a potential candidate for the development of medications aimed at treating conditions such as insomnia, anxiety disorders, and other related conditions where sedation and calming effects are desired.
Used in Research and Development:
In addition to its potential therapeutic applications, U 90042 can also be used as a research tool to study the function and modulation of GABAA receptors. This can help scientists better understand the underlying mechanisms of various neurological and psychiatric disorders, as well as develop new and more effective treatments for these conditions.
Used in Drug Delivery Systems:
Similar to gallotannin, U 90042 can also benefit from novel drug delivery systems to enhance its applications and efficacy. By employing various organic and metallic nanoparticles as carriers for U 90042 delivery, researchers can improve its delivery, bioavailability, and therapeutic outcomes, potentially leading to more effective treatments for conditions that respond to sedative and hypnotic agents.
Biological Activity
GABA A receptor ligand that binds with comparable affinities to three receptor subtypes: α 1 β 2 γ 2 , α 3 β 2 γ 2 and α 6 β 2 γ 2 (K i values are 7.8, 9.5 and 11.0 nM respectively). Potentiates GABA-induced chloride currents in α 6 β 2 γ 2 receptors. Sedative/hypnotic compound.
Check Digit Verification of cas no
The CAS Registry Mumber 134516-99-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,4,5,1 and 6 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 134516-99:
(8*1)+(7*3)+(6*4)+(5*5)+(4*1)+(3*6)+(2*9)+(1*9)=127
127 % 10 = 7
So 134516-99-7 is a valid CAS Registry Number.
134516-99-7Relevant articles and documents
Heterocyclic compounds and their preparation and use
-
, (2008/06/13)
New imidazoquinazoline compounds having the general formula STR1 wherein A together with the α-marked carbon atom and the β-marked nitrogen atom is one of the groups STR2 wherein R4, R5, R6 and R7 independently are hydrogen, halogen C1-6 -alkyl, aryl or aralkyl R1 is STR3 cyano or CO2 R8, wherein R8 is hydrogen, C1-6 -alkyl or C3-7 -cycloalkyl, trifluoromethyl or C1-6 -alkoxymethyl, R2 and R3 independently are hydrogen, halogen, CN, C1-6 -alkyl, C2-6 -alkenyl, C2-6 -alkynyl, trifluoromethyl, C1-6 -alkoxy, dialkylaminoalkoxy, aralkoxy, aryloxy which may be substituted with halogen or alkoxy, a cyclic amino group, or NR9 R10, wherein R9 and R10 independently are hydrogen or C1-6 -alkyl. The compounds are useful in psychopharmaceutical preparations as anticonvusants, anxiolytics, hypnotics, antipsychotics, antiemetics, or in improving the cognitive function of the brain of mammals.