134924-68-8

Basic information

• Product Name: cis-Hydroxy Praziquantel
• Synonyms: cis-Hydroxy Praziquantel;1,2,3,6,7,11b-Hexahydro-2-[(cis-4-hydroxycyclohexyl)carbonyl]-4H-pyrazino[2,1-a]isoquinolin-4-one;cis-(+/-)-1,2,3,6,7,11b-Hexahydro-2-[(4-hydroxycyclohexyl)carbonyl]- 4H-pyrazino[2,1-a]isoquinolin-4-one
• CAS NO: 134924-68-8
• Molecular Formula: C₁₉H₂₄N₂O₃
• Molecular Weight: 328.40546
• Product Categories: Aromatics;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Aromatics, Chiral Reagents, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 134924-68-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 591.3°C at 760 mmHg
• Flash Point: 311.4°C
• Appearance: /
• Density: 1.3g/cm³
• Vapor Pressure: 7.9E-15mmHg at 25°C
• Refractive Index: 1.634
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Ethanol (Slightly, Sonicated), Ethyl Acetate (Slightly),
• CAS DataBase Reference: cis-Hydroxy Praziquantel(CAS DataBase Reference)
• NIST Chemistry Reference: cis-Hydroxy Praziquantel(134924-68-8)
• EPA Substance Registry System: cis-Hydroxy Praziquantel(134924-68-8)

Safety Data

• Hazardous Substances Data: 134924-68-8(Hazardous Substances Data)

Usage

Description

cis-Hydroxy Praziquantel, also known as the main cis-monohydroxylated metabolite of Praziquantel (P702095), is a white solid substance. It is derived from the metabolism of Praziquantel, a widely used antiparasitic drug. The presence of hydroxy groups in its chemical structure allows for potential interactions with various biological molecules, making it a compound of interest for further research and development in the pharmaceutical field.

Uses

Used in Pharmaceutical Applications:
cis-Hydroxy Praziquantel is used as an active metabolite for enhancing the efficacy of antiparasitic treatments. As a metabolite of Praziquantel, it contributes to the overall effectiveness of the drug against various parasitic infections, including schistosomiasis and tapeworm infestations.
Used in Research and Development:
cis-Hydroxy Praziquantel is used as a research compound for studying the metabolic pathways and pharmacological effects of Praziquantel. This knowledge can be applied to optimize drug formulations, improve drug delivery, and develop new therapeutic strategies for parasitic diseases.
Used in Drug Metabolism Studies:
cis-Hydroxy Praziquantel is used as a model compound in drug metabolism studies, helping researchers understand how drugs are processed and eliminated from the body. This information is crucial for predicting drug interactions, assessing potential side effects, and guiding the design of safer and more effective medications.
Used in Drug Synthesis:
cis-Hydroxy Praziquantel can be used as a starting material or intermediate in the synthesis of novel antiparasitic drugs. Its unique chemical properties may allow for the development of new compounds with improved potency, selectivity, and reduced side effects.

InChI:InChI=1/C19H24N2O3/c22-15-7-5-14(6-8-15)19(24)20-11-17-16-4-2-1-3-13(16)9-10-21(17)18(23)12-20/h1-4,14-15,17,22H,5-12H2

Upstream product

• 57452-32-1 2-(4-oxocyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino<2,1-a>isoquinolin-4-one 
• 55268-74-1 2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one 
• 874-61-3 4-oxocyclohexanecarboxylic acid 
• 6297-22-9 4-carbomethoxycyclohexanone 
• 914637-80-2 4-oxocyclohexane carboxylic acid chloride 

Relevant articles and documents

Synthesis and properties of cis- and trans-4-hydroxypraziquantel

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