135005-24-2Relevant articles and documents
Synthesis of Enantiopure C3-Symmetric Triangular Molecules
Miura, Tomoya,Nakamuro, Takayuki,Stewart, Scott G.,Nagata, Yuuya,Murakami, Masahiro
, p. 3334 - 3338 (2017)
An asymmetric synthesis of C3-symmetric triangular macrocycles is reported. 1-Methylsulfonyl-4-(4-vinylphenyl)-1,2,3-triazole undergoes a rhodium(II)-catalyzed cyclotrimerization to establish an enantiopure C3-symmetric triangular ma
Zinc-Catalysed Hydroboration of Terminal and Internal Alkynes
Mandal, Souvik,Mandal, Sayantan,Geetharani
, p. 4553 - 4556 (2019/08/20)
A regioselective hydroboration of alkynes has been developed by using commercially available zinc triflate as a catalyst, in the presence of catalytic amount of NaBHEt3. The reaction tolerates a wide range of terminal alkynes having several synthetically useful functional groups and proceeds regioselectively to furnish hydroborated products in moderate to excellent yields. This system shows moderate chemoselectivity towards terminal C≡C bond over terminal and internal C=C bond and internal C≡C bond.
MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS
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Paragraph 00621; 00791, (2018/09/12)
Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.